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• W2186547722 abstract "The present study investigates the trypanocidal activity of Tapinanthus <em>globiferus</em> and <em>Gongronema latifolium</em> on <em>Trypanosoma brucei brucei</em> <em>In vitro</em> and <em>In vivo</em>. Various extracts obtained from these plants, were compared for trypanocidal activity <em>In vitro</em> and <em>In vivo</em> at different concentration. The methanolic extract of <em>Tapinanthus globiferus</em> and <em>Gongrenema latifolium</em> had the highest activity <em>In vitro</em> and were further evaluated for in vivo activity on mice infected with <em>Trpanosoma brucei brucei</em>. The groups were treated with extract concentration ranging from 100-400mg/kg of body weight intraperitoneally for 7 consecutive days. The group treated with 400mg/kg of <em>Tapinanthus globiferus</em> had significant reduction in parasiteamia and their life span was prolonged up to the 20-21st day, in comparison to those treated with the same dose of <em>Gongrenema latifolium</em> and all other groups treated with other doses, including the control, all died between day 5th-8th post infection. The group treated with extract of <em>Tapinanthus globiferus</em> and inoculated with parasite simultaneously did not develop parasite until the 9th day with low level of parasiteamia, with appreciable life span ranging between 15-16 days post infection. The Phytochemical screening showed appreciable amount of alkaloids and flavonoids in the extract of <em>Tapinanthus globiferus</em> compared to that found in <em>Gongrenema latifolium</em> which were only in traces." @default.
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• W2186547722 date "2013-06-20" @default.
• W2186547722 modified "2023-09-27" @default.
• W2186547722 title "Comparative Studies of <em>In vitro</em>, <em>In vivo</em> Trypanocidal Activity and Phytochemical Screening of <em>Tapinanthus globiferus</em> and <em>Gongronema latifolium</em>" @default.
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• W2186547722 doi "https://doi.org/10.19026/ijava.5.5587" @default.
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