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• W2186564659 abstract "Summary Paskalev, M., 2011. Relationship between blood malondialdehyde and catalase concentra� tions and the time of occurrence of nonfixed long bone fractures in dogs. Bulg. J. Vet. Med. , 14, No 4, 231 −237. The purpose of the present study was to follow out the blood concentrations of malondialdehyde (MDA), an end product of lipid peroxidation and the activity of one of antioxidant defense enzymes - catalase (CAT), in dogs with long bone fractures. Forty eight dogs with single fractures of the humerus, radius and ulna, femur and tibia were included. Depending on the time elapsed from the trauma to the referral in the clinic and blood sample collection, 7 time periods were formed: less than 12 h; 12-24 h; 24-72 h; 3-6 days; 1-2 weeks; 2-4 weeks; 4-8 weeks. Blood samples were obtained during the initial examination and before the surgery. Another 36 clinically healthy adult dogs aged 2 to 6 years served as controls. Statistically significantly higher MDA concentrations were observed in fractures with < 12 h elapsed from the accident. They remained elevated in dogs with bones fractured up to 2 weeks ago (p<0.001). In dogs with 2 to 4 weeks old fractures, they were lower and increased again in fractures occurring 4-8 weeks ago (P<0.05). The activity of catalase was significantly higher at time from fracture periods 12-24 h (p<0.001), 3-6 days (p<0.001) and 1-2 weeks (p<0.001). The results demonstrated high extent of blood lipid peroxidation together with increased catalase activity in dogs with accidental nonfixed fractures of long bones in dogs which occurred up to 2 weeks ago. It could be therefore affirmed that all methods and treatment options that would reduce blood MDA concentrations in the early post fracture period and at the same time, maintain an adequate level of the antioxidant defense, would be beneficial for the timely and proper bone healing." @default.
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• W2186564659 date "2011-01-01" @default.
• W2186564659 modified "2023-09-23" @default.
• W2186564659 title "Relationship between blood malondialdehyde and catalase concentrations and the time of occurrence of non-fixed long bone fractures in dogs." @default.
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