FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186571892> ?p ?o ?g. }

• W2186571892 endingPage "602" @default.
• W2186571892 startingPage "593" @default.
• W2186571892 abstract "Evaluate the hypnotic efficacy of gaboxadol, a selective extrasynaptic GABAA agonist (SEGA), in a phase advance model of transient insomnia. A randomized, double-blind, cross-over study in which habitual sleep time was advanced by 4 h. Sleep research laboratories 109 healthy subjects (18–58 y) Gaboxadol 5 mg, 10 mg, and 15 mg (GBX5, GBX10, GBX15) versus placebo (PBO). Zolpidem 10 mg (ZOL10) was used as an active reference. Polysomnographic (PSG) and self-reported (s) sleep measures Wakefulness after sleep onset (WASO) decreased (P <0.05) and total sleep time (TST) increased (P <0.001) in all treatments versus PBO. Latency to persistent sleep was shorter (P <0.05) than PBO for all treatments except GBX5. GBX10 and GBX15 increased slow wave activity (SWA; 0.75–4.5 Hz, P <0.001) and theta activity (4.75–7.75Hz; P <0.001) and reduced sigma activity (12.25–15.0 Hz; significant for GBX15 only, P <0.001) compared to PBO in NREM sleep EEG, in a dose-response manner. Zolpidem suppressed power density over a broad low frequency range including delta and theta frequencies (2.25–8.0 Hz, P <0.05) and also enhanced sigma activity (P <0.001). Self-reported sWASO and sTST improved for all treatments versus PBO (P <0.05). Self-reported sleep latency was reduced following GBX10 (P <0.05) and ZOL10 (P <0.001). Neither drug treatment was associated with residual effects the morning after treatment. Gaboxadol and zolpidem improved objective and subjective efficacy measures in this model of transient insomnia. The gaboxadol-induced enhancement of SWA and theta activity and the reduction of sigma activity contrasts with zolpidem's effects on the spectral EEG. These differences may reflect the different mechanisms of action of the two drugs." @default.
• W2186571892 created "2016-06-24" @default.
• W2186571892 creator A5016898204 @default.
• W2186571892 creator A5021520831 @default.
• W2186571892 creator A5024183255 @default.
• W2186571892 creator A5080896827 @default.
• W2186571892 date "2007-05-01" @default.
• W2186571892 modified "2023-10-13" @default.
• W2186571892 title "The Selective Extrasynaptic GABAA Agonist, Gaboxadol, Improves Traditional Hypnotic Efficacy Measures and Enhances Slow Wave Activity in a Model of Transient Insomnia" @default.
• W2186571892 cites W10150358 @default.
• W2186571892 cites W1503425915 @default.
• W2186571892 cites W1521227715 @default.
• W2186571892 cites W17292231 @default.
• W2186571892 cites W1964357132 @default.
• W2186571892 cites W1965376023 @default.
• W2186571892 cites W1970073498 @default.
• W2186571892 cites W1972852256 @default.
• W2186571892 cites W1973171009 @default.
• W2186571892 cites W1975395144 @default.
• W2186571892 cites W1979404766 @default.
• W2186571892 cites W1990687924 @default.
• W2186571892 cites W1998068393 @default.
• W2186571892 cites W2002293846 @default.
• W2186571892 cites W2021950020 @default.
• W2186571892 cites W2024108692 @default.
• W2186571892 cites W2027358017 @default.
• W2186571892 cites W2044613992 @default.
• W2186571892 cites W2051589707 @default.
• W2186571892 cites W2060392742 @default.
• W2186571892 cites W2061947653 @default.
• W2186571892 cites W2062186332 @default.
• W2186571892 cites W2065546220 @default.
• W2186571892 cites W2066935851 @default.
• W2186571892 cites W2074671627 @default.
• W2186571892 cites W2080659194 @default.
• W2186571892 cites W2082699503 @default.
• W2186571892 cites W2083019750 @default.
• W2186571892 cites W2137143812 @default.
• W2186571892 cites W2151487996 @default.
• W2186571892 cites W2158446241 @default.
• W2186571892 cites W2159502931 @default.
• W2186571892 cites W2194118660 @default.
• W2186571892 cites W2210670334 @default.
• W2186571892 cites W2273859037 @default.
• W2186571892 cites W2329622814 @default.
• W2186571892 cites W2399025129 @default.
• W2186571892 cites W2409818457 @default.
• W2186571892 cites W2417523335 @default.
• W2186571892 cites W2417912569 @default.
• W2186571892 cites W2419602943 @default.
• W2186571892 cites W3022302886 @default.
• W2186571892 cites W761239894 @default.
• W2186571892 cites W98688011 @default.
• W2186571892 doi "https://doi.org/10.1093/sleep/30.5.593" @default.
• W2186571892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17552374" @default.
• W2186571892 hasPublicationYear "2007" @default.
• W2186571892 type Work @default.
• W2186571892 sameAs 2186571892 @default.
• W2186571892 citedByCount "82" @default.
• W2186571892 countsByYear W21865718922012 @default.
• W2186571892 countsByYear W21865718922013 @default.
• W2186571892 countsByYear W21865718922014 @default.
• W2186571892 countsByYear W21865718922015 @default.
• W2186571892 countsByYear W21865718922016 @default.
• W2186571892 countsByYear W21865718922017 @default.
• W2186571892 countsByYear W21865718922018 @default.
• W2186571892 countsByYear W21865718922019 @default.
• W2186571892 countsByYear W21865718922020 @default.
• W2186571892 countsByYear W21865718922021 @default.
• W2186571892 countsByYear W21865718922022 @default.
• W2186571892 crossrefType "journal-article" @default.
• W2186571892 hasAuthorship W2186571892A5016898204 @default.
• W2186571892 hasAuthorship W2186571892A5021520831 @default.
• W2186571892 hasAuthorship W2186571892A5024183255 @default.
• W2186571892 hasAuthorship W2186571892A5080896827 @default.
• W2186571892 hasBestOaLocation W21865718921 @default.
• W2186571892 hasConcept C110539466 @default.
• W2186571892 hasConcept C118552586 @default.
• W2186571892 hasConcept C126322002 @default.
• W2186571892 hasConcept C134018914 @default.
• W2186571892 hasConcept C15744967 @default.
• W2186571892 hasConcept C170493617 @default.
• W2186571892 hasConcept C2777123777 @default.
• W2186571892 hasConcept C2778938600 @default.
• W2186571892 hasConcept C2780930544 @default.
• W2186571892 hasConcept C2781053850 @default.
• W2186571892 hasConcept C2781210498 @default.
• W2186571892 hasConcept C42219234 @default.
• W2186571892 hasConcept C522805319 @default.
• W2186571892 hasConcept C63759246 @default.
• W2186571892 hasConcept C71924100 @default.
• W2186571892 hasConcept C98274493 @default.
• W2186571892 hasConceptScore W2186571892C110539466 @default.
• W2186571892 hasConceptScore W2186571892C118552586 @default.
• W2186571892 hasConceptScore W2186571892C126322002 @default.
• W2186571892 hasConceptScore W2186571892C134018914 @default.
• W2186571892 hasConceptScore W2186571892C15744967 @default.
• W2186571892 hasConceptScore W2186571892C170493617 @default.

• next