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- W2186594571 abstract "Introduction Under the flagship of the tropical disease research programme of the WHO, the search for a new therapeutic modality against human lymphatic filariasis has emerged as a thrust driven area of research considering massive socioeconomic burden associated with this disease. However, given the technical limitation of procuring parasite material from suitable animal model and huge financial burden for resource intensive in-depth research, there is need for a target specific approach. This study targets physical effect of nanoparticles on drug development against filariasis. The Hypothesis Available evidence suggests apoptosis as a plausible rationale, hence essential parasitic proteins with potential for proliferation may be considered as a prospective target. In order to achieve precision in darting them, agents with specific affinity might be exploited. In this context thermodynamic affinity between high entropy surface plasmon of nanoparticles and thiol residue of target proteins for mutual interaction may prove to be apposite. Such interaction is expected to result in conformational and consequent functional derangement of the target protein. Evaluation of hypothesis For this purpose, we have bioinformatically searched with precise criterion to retrieve essential thiol proteins from B. malayi proteome database. Further, growth associated proteins from this shortlist were selected as possible targets. Representative proteins like ubiquitin C terminal hydrolase for its prominent role in cell cycle regulation, might be allowed for exposure with nanoparticles in silico, followed by authentication through real experimental evidence. Conclusion If successful, this unique method may not only provide a valid therapeutic modality for this parasitic disease but also might develop newer insight into the physiology of parasitic growth through nano-protein interactions to be utilized in the future." @default.
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- W2186594571 date "2014-01-01" @default.
- W2186594571 modified "2023-09-24" @default.
- W2186594571 title "Exploiting nanoparticle for targeted apoptosis as therapeutic modality against filarial parasite: A plausible premise" @default.
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