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- W2186606445 abstract "ofthegrowthabnormalities in sickle cell disease hasbeenlimited bythe lackoflongitudinal observations inindi- viduals, andbyaninability toquantitate theobserved patterns. Toinvestigate the timingand patternoftheadolescent growthspurt, longitudinal observations of heightfromtheJamaicancohortstudy werefitted toa mathematical modelof growth(Preece-Baines model1).The studyincluded 44children withhomo- zygous sickle cell (SS)disease, 44ageand sexmatchedsubjects withsickle cell haemoglobin C (SC)disease, and44age andsexmatchedcontrols withnormal (AA)haemoglobin. ComparedwithAA controls, theonset of the adolescent growthspurtwas delayed inSSdisease by14 years(95% confidence interval 0-8to2.0)withno significant sexdifference. Theageatpeak height velocity wasdelayed by1*6years (0.9to2.3)inSS comparedwithAA subjects buttheadolescent growthofSS children wasotherwise normalandthere wasnodifference intheattained height byage17*9 years. Thegrowthspurtwas notdelayed inSC disease. Theageat menarcheingirls withSSdisease (mean (SD)15*4(1.3) years) wassignificantly later thangirls withSCdisease (13.7 (1.7) years) andthosewithAA haemoglobin (13.1(1.3) years)butthesegenotype differences were no longersignificant aftercontrolling forthedelayinthe adolescent growthspurt.The normally coordinated butslightly delayed pattern of growthandnormaladult heights suggests a goodprognosis foradolescent growth delay inSS disease. Mostchildren with SS disease cantherefore be reassured on theoutcomeofretarded adolescent growth. DisChild 1994; 71:404-408)" @default.
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- W2186606445 date "1994-01-01" @default.
- W2186606445 modified "2023-09-27" @default.
- W2186606445 title "Delayed adolescent growth inhomozygous sickle cell disease" @default.
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