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- W2186618149 abstract "An increasing number of genetic-association studies have implicated polymorphisms of cytokine genes as host genetic factors that influence susceptibility to autoimmunity, infectious disease, and transplantation tolerance. Tumor necrosis factor α (TNF-α) is representative of a pro-inflammatory cytokine that can counteract the anti-inflammatory interleukin 10 (IL-10) to maintain an inflammatory milieu that favors conditions such as septic shock, allograft rejection, and other disease processes. Cytokine production is under genetic control, and certain single nucleotide polymorphisms (SNPs), which lead to allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro. We have analyzed the genetic variations in the promoter region of TNF-α and IL-10 with real-time amplification and melting curve analysis of the LightCycler Instrument. When compared to sequence-specific polymerase chain reaction (PCR-SSP) analysis, the results obtained on the LightCycler were rapid, reproducible, and more reliable than the conventional methodology." @default.
- W2186618149 created "2016-06-24" @default.
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- W2186618149 date "2003-01-01" @default.
- W2186618149 modified "2023-09-24" @default.
- W2186618149 title "Identification of Cytokine SNPs Using LightCycler Hybridization Probes and Melting Curve Analysis" @default.
- W2186618149 hasPublicationYear "2003" @default.
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