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• W2186638875 abstract "Vetiveria zizanioides roots possess anthelmintic, antimicrobial and in-vitro antioxidant activity. The aim of present study was to evaluate the hepatoprotective potential of methanolic extract of Vetiveria Zizanioides roots (MEVZ) against CCL4-induced acute liver damage in rats. Animals were pretreated with MEVZ (300 and 500 mg/kg, p.o) and silymarin (200 mg/kg, p.o) respectively 30 min prior to CCL4 (0.5 ml/kg, i.p) ingestion for 7 days. The effects of MEVZ were assessed directly by liver histology and by serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphate (ALP), total and direct bilirubin (TBL & DBL), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), total protein (TP), liver malondialdehyde (MDA) and reduced glutathione (GSH). Also Serum Interleukin (IL-6), IL-1β and Tumor necrosis factor-α (TNF-α) were measured by enzyme linked immunosorbent assay (ELISA). CCl4-induced acute liver damage offers a protection in MEVZ treated rats and its effects are comparable with standard drug silymarin. The data indicated that ALT, AST, ALP, TBL, DBL, LDH, GGT, MDA, IL-6, IL-1β and TNF-α level were significantly increased and decreased in GSH and TP levels in CCL4 control. We found significantly reversal in all above parameters in treated groups. Our results clearly suggest hepatoprotective potentials of MEVZ mediated through attenuation of TNF-α and Il-6 mediated pathways, indicates it as a novel herbal drug for the prevention of acute liver damage." @default.
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• W2186638875 date "2013-01-01" @default.
• W2186638875 modified "2023-09-26" @default.
• W2186638875 title "HEPATOPROTECTIVE POTENTIAL OF METHANOLIC EXTRACT OF VETIVERIA ZIZANIOIDES ROOTS AGAINST CARBON TETRACHLORIDE- INDUCED ACUTE LIVER DAMAGE IN RATS" @default.
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