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- W2186686739 abstract "Doxorubicin (Dox) is a common chemotherapeutic anticancer drug. One of its side effect, according to s ome studies is oxidative stress-induced toxic changes on the liver . In this study protective efficacy of Proanthocyan idin (GSPE) along with vitamin E on Dox induced hepatotoxicity was evaluated in 50 male (divided in to five groups) Wister ra ts. After 2 weeks of the experiment and drug administration, blood sampl es and liver tissues were taken from all groups. Li pid profiles, liver function test in blood serum and Superoxide Dismutase (SOD), Catalase (CAT) and Malondialdehyde (MDA) levels in liver tissue were measured. We found that intraperi tonial administration of Dox had profound effects o n the liver as assessed by liver function tests and liver histolog y. The present results showed that pretreatment wit h proanthocyanidin extract, along with vitamin E enhances the antioxid ant defense against Reactive Oxygen Species and red uced the oxidative stress and change in activity of antioxidant enzyme s induced by Dox, thereby demonstrating the antioxi dant potential of GSPE along with vitamin E in ameliorating the hepatotoxicity induced by Dox and it shows that it could be one approach to reduce the risk of Dox induced side effects in clin ical settings." @default.
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- W2186686739 date "2012-01-01" @default.
- W2186686739 modified "2023-09-24" @default.
- W2186686739 title "Prophylactic Efficacy of a Combination of Proanthocyanidin and Vitamin E on Hepatotoxicity Induced by Doxorubicin in Rats" @default.
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