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• W2186694118 abstract "The signal transduction pathway for A 1 adenosine receptor in airway smooth muscle from allergic rabbits was studied by investigating the effect of the selective A 1 adenosine-receptor agonist N 6 -cyclopentyladenosine (CPA) on tissue levels of inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ] measured by protein binding assay. CPA caused a rapid, transient, and concentration-dependent elevation of Ins(1,4,5) P 3 in airways from allergic rabbits. The agonist also produced a concentration-dependent contraction of the airway preparations from these animals. Both the Ins(1,4,5) P 3 and contractile responses generated by CPA were attenuated by the phospholipase C (PLC) inhibitor U-73122, indicating the coupling of these responses to PLC. The CPA-induced Ins(1,4,5) P 3 production observed in the allergic rabbit tissues was also inhibited by the adenosine-receptor antagonist 8-( p-sulfophenyl)-theophylline, suggesting that the effect was mediated by A 1 adenosine receptors. On the other hand, the A 2 adenosine-receptor agonist CGS-21680 was ineffective in altering the tissue concentration of Ins(1,4,5) P 3 , indicating that A 2 adenosine receptors may not be involved in the activation of PLC in the allergic rabbit airway smooth muscle. In this preparation, the G i -G o inhibitor pertussis toxin (PTX) attenuated the CPA-induced Ins(1,4,5) P 3 accumulation, providing evidence that the generation of Ins(1,4,5) P 3 by A 1 adenosine-receptor stimulation is coupled to a PTX-sensitive G protein(s). The results suggest that activation of A 1 adenosine receptors in allergic rabbit airway smooth muscle causes the production of Ins(1,4,5) P 3 via a PTX-sensitive G protein-coupled PLC, and this signaling mechanism may be involved, at least in part, in the generation of contractile responses. It is hypothesized that this process may contribute to adenosine-induced bronchoconstriction in allergic asthma." @default.
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• W2186694118 date "1998-11-01" @default.
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• W2186694118 title "A₁adenosine receptor-mediated Ins(1,4,5)<i>P</i>₃generation in allergic rabbit airway smooth muscle" @default.
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• W2186694118 doi "https://doi.org/10.1152/ajplung.1998.275.5.l990" @default.
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