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• W2186706089 startingPage "573" @default.
• W2186706089 abstract "The purpose of this study was to elucidate the roles of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in the lipoprotein derangement of cystic fibrosis (CF) patients with respect to their essential fatty acid (EFA) status. Triglyceride enrichment and cholesteryl ester (CE) depletion were observed in the lipoproteins of 22 CF patients. The abnormal chemical composition was more severe in 12 EFA-deficient (EFAD) than in 10 EFA-sufficient (EFAS) patients. Expressed in nmol.L-1.h-1, LCAT activity was higher (P < 0.05) in both EFAS (mean +/- SE, 92.7 +/- 1.9) and EFAD (108.8 +/- 3.0) patients than in control subjects (65.2 +/- 0.9). An equal CE transfer was recorded in the lipoprotein-deficient serum, as a source of CETP activity, in all groups studied by using normal exogenous low-density lipoprotein (LDL) and high-density lipoprotein (HDL). However, in contrast to the maximal amount of CE transferred from endogenous HDL to endogenous apolipoprotein B (apo B) in control subjects, a reduction in CETP activity was seen in CF patients and more pronounced in the EFAD group. These findings indicate that impaired lipoprotein composition may have marked effects on the transfer of CE between HDL and apo B in EFAD CF patients." @default.
• W2186706089 created "2016-06-24" @default.
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• W2186706089 date "1993-04-01" @default.
• W2186706089 modified "2023-09-30" @default.
• W2186706089 title "Lipoprotein abnormalities associated with cholesteryl ester transfer activity in cystic fibrosis patients: the role of essential fatty acid deficiency" @default.
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• W2186706089 doi "https://doi.org/10.1093/ajcn/57.4.573" @default.
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