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• W2186718199 abstract "Background: In our published randomized trial in colorectal cancer, group 1 (n = 37) received individualized nutritional counseling and education about regular foods, group 2 (n = 37) received dietary supplements and consumed their usual diet of regular foods, and group 3( n = 37) consumed their usual diet of regular foods. Neither group 2 nor group 3 received individualized counseling. Early nutritional counseling during radiotherapy was highly effective at reducing acute radiotherapy toxicity and improving nutritional intake/status and quality of life (QoL). Efficacy persisted for 3 mo after the intervention. Objective: The objective was to perform long-term follow-up in survivors of that clinical trial to specifically evaluate survival, late toxicity, QoL, and nutritional variables. Design: Medical data were collected from patients’ records, and prescheduled interviews were conducted by dietitians for individualized evaluations. Analyses and comparisons between groups (adjusted for stage) were performed after a median follow-up of 6.5 (range: 4.9‐8.1) y. Results: Patients complied with the Radiotherapy Department’s follow-up protocol. Nutritional deterioration was higher (P , 0.001) in group 3 (n = 26) and group 2 (n = 29) than in group 1 (n =3 4). Adequate nutritional status was maintained in 91% of group 1 patients but not in any of the group 3 patients (P , 0.002). Intakes in group 1 were similar to reference values, and the patients adhered to the prescribed recommendations. Intakes in groups 2 and 3 were lower than recommended intakes: group 3 x group 2 , group 1 (P =0 .001). Median survival in group 3 was 4.9 y (30% died), in group 2 was 6.5 y (22% died), and in group 1w as 7.3 y( only 8% died): group 3. group 2 . group 1( P , 0.01). Late radiotherapy toxicity was higher in group 3( n =1 7; 65%) and group 2( n = 17; 59%) than in group 1 (n =3 ; 9%): group 3 x group 2 . group 1( P , 0.001). QoL was worse in groups 3 and 2 than in group group 3 x group 2 , group 1: (P , 0.002). Worse radiotherapy toxicity, QoL, and mortality were associated with deteriorated nutritional status and intake (P , 0.001). Likewise, depleted intake, nutritional status, and QoL predicted shorter survival and late toxicity (HR: 8.25; 95% CI: 2.74, 1.47; P , 0.001). Conclusions: This study conveys novel information about the effecti veness of nutrition at improving long-term prognosis in colorectal cancer. Overall, the data indicate that early individualized nutritional counseling and education during radiotherapy is valuable for patients. Am J Clin Nutr doi: 10.3945/ajcn.111.018838." @default.
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• W2186718199 title "Individualized nutrition intervention is of major benefit to colorectal cancer patients: long-term follow-up of a randomized controlled trial of" @default.
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