Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186719595> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2186719595 endingPage "43" @default.
- W2186719595 startingPage "1936" @default.
- W2186719595 abstract "The significance of L-[methyl-11C]methionine (11C-Met), L-[1-11C]leucine (11C-Leu) and L-2-[18F]fluorotyrosine (18F-Tyr) for measuring protein synthesis rates in the brain and in tumors by PET was re-evaluated. Tissue uptake and protein incorporation of 3H-Met, 14C-Leu and 18F-Tyr were investigated in mice bearing the FM3A mammary carcinoma. In the control group, the uptake of all three tracers in the brain and FM3A and their incorporation into the acid-precipitable fraction (APF) increased over 60 min. When the protein synthesis in vivo was inhibited by cycloheximide, the incorporation of all three tracers into the APF was significantly reduced to 6%-32% and 3%-11% of the control in the brain and FM3A, respectively. Under these conditions, total uptake of 14C-Leu in the brain and FM3A decreased rapidly, and most of the 14C in the APF was detected as proteins. On the other hand, 3H-Met and 18F-Tyr uptake continued to increase, and significant amounts of radioactivity were incorporated into nonprotein materials. In mice given ouabain to inhibit amino acid transport, total uptake of all three amino acids by FM3A was reduced to 67%-74% of the control 5 min postinjection. These results demonstrate that uptake of the three amino acids is affected by alterations in the amino acid transport system in the brain and tumor tissues, but that only 14C-Leu uptake reflects protein synthesis rates." @default.
- W2186719595 created "2016-06-24" @default.
- W2186719595 creator A5006698038 @default.
- W2186719595 creator A5034162457 @default.
- W2186719595 creator A5040830735 @default.
- W2186719595 creator A5059414275 @default.
- W2186719595 creator A5060839417 @default.
- W2186719595 creator A5060970883 @default.
- W2186719595 creator A5078683191 @default.
- W2186719595 date "1993-11-01" @default.
- W2186719595 modified "2023-10-02" @default.
- W2186719595 title "Re-evaluation of amino acid PET studies: can the protein synthesis rates in brain and tumor tissues be measured in vivo?" @default.
- W2186719595 cites W1577460613 @default.
- W2186719595 cites W2023600190 @default.
- W2186719595 cites W2081868313 @default.
- W2186719595 cites W2147427577 @default.
- W2186719595 cites W2158246530 @default.
- W2186719595 cites W2402997235 @default.
- W2186719595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8229238" @default.
- W2186719595 hasPublicationYear "1993" @default.
- W2186719595 type Work @default.
- W2186719595 sameAs 2186719595 @default.
- W2186719595 citedByCount "77" @default.
- W2186719595 countsByYear W21867195952013 @default.
- W2186719595 countsByYear W21867195952014 @default.
- W2186719595 countsByYear W21867195952015 @default.
- W2186719595 countsByYear W21867195952016 @default.
- W2186719595 countsByYear W21867195952017 @default.
- W2186719595 countsByYear W21867195952018 @default.
- W2186719595 countsByYear W21867195952019 @default.
- W2186719595 countsByYear W21867195952021 @default.
- W2186719595 countsByYear W21867195952023 @default.
- W2186719595 crossrefType "journal-article" @default.
- W2186719595 hasAuthorship W2186719595A5006698038 @default.
- W2186719595 hasAuthorship W2186719595A5034162457 @default.
- W2186719595 hasAuthorship W2186719595A5040830735 @default.
- W2186719595 hasAuthorship W2186719595A5059414275 @default.
- W2186719595 hasAuthorship W2186719595A5060839417 @default.
- W2186719595 hasAuthorship W2186719595A5060970883 @default.
- W2186719595 hasAuthorship W2186719595A5078683191 @default.
- W2186719595 hasConcept C150903083 @default.
- W2186719595 hasConcept C178790620 @default.
- W2186719595 hasConcept C185592680 @default.
- W2186719595 hasConcept C202751555 @default.
- W2186719595 hasConcept C207001950 @default.
- W2186719595 hasConcept C2776580952 @default.
- W2186719595 hasConcept C2778128677 @default.
- W2186719595 hasConcept C2779133857 @default.
- W2186719595 hasConcept C2780912031 @default.
- W2186719595 hasConcept C3675279 @default.
- W2186719595 hasConcept C515207424 @default.
- W2186719595 hasConcept C537181965 @default.
- W2186719595 hasConcept C55493867 @default.
- W2186719595 hasConcept C86803240 @default.
- W2186719595 hasConceptScore W2186719595C150903083 @default.
- W2186719595 hasConceptScore W2186719595C178790620 @default.
- W2186719595 hasConceptScore W2186719595C185592680 @default.
- W2186719595 hasConceptScore W2186719595C202751555 @default.
- W2186719595 hasConceptScore W2186719595C207001950 @default.
- W2186719595 hasConceptScore W2186719595C2776580952 @default.
- W2186719595 hasConceptScore W2186719595C2778128677 @default.
- W2186719595 hasConceptScore W2186719595C2779133857 @default.
- W2186719595 hasConceptScore W2186719595C2780912031 @default.
- W2186719595 hasConceptScore W2186719595C3675279 @default.
- W2186719595 hasConceptScore W2186719595C515207424 @default.
- W2186719595 hasConceptScore W2186719595C537181965 @default.
- W2186719595 hasConceptScore W2186719595C55493867 @default.
- W2186719595 hasConceptScore W2186719595C86803240 @default.
- W2186719595 hasIssue "11" @default.
- W2186719595 hasLocation W21867195951 @default.
- W2186719595 hasOpenAccess W2186719595 @default.
- W2186719595 hasPrimaryLocation W21867195951 @default.
- W2186719595 hasRelatedWork W118575299 @default.
- W2186719595 hasRelatedWork W1600804495 @default.
- W2186719595 hasRelatedWork W2000612170 @default.
- W2186719595 hasRelatedWork W2002111026 @default.
- W2186719595 hasRelatedWork W2044736076 @default.
- W2186719595 hasRelatedWork W2056894233 @default.
- W2186719595 hasRelatedWork W2068686164 @default.
- W2186719595 hasRelatedWork W2091524209 @default.
- W2186719595 hasRelatedWork W2186719595 @default.
- W2186719595 hasRelatedWork W319955201 @default.
- W2186719595 hasVolume "34" @default.
- W2186719595 isParatext "false" @default.
- W2186719595 isRetracted "false" @default.
- W2186719595 magId "2186719595" @default.
- W2186719595 workType "article" @default.