Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186725344> ?p ?o ?g. }
- W2186725344 abstract "We extend our earlier work on the influence of environmental availability of nicotine by increasing the concentrations of oral nicotine solutions and by using gas chromatography-mass spectrometry (GC-MS) applications to examine nicotine and its primary metabolite cotinine in the blood serum. Sprague Dawley rats were chronically exposed to nicotine solutions (5μg/ml and 8μg/ml) through drinking bottles in their home cage. At the end of oral nicotine exposure, blood serum was analyzed by GC-MS for nicotine and cotinine content. Intake results supported previous studies showing rats will readily and voluntarily ingest oral nicotine, even at relatively high concentrations. Further, GC-MS results indicated nicotine in the majority of spiked and unspiked samples, but with wide variations in nicotine serum counts. Although GC techniques need to be refined, this study is the first to establish that nicotine concentrations delivered via a truly voluntary oral route results in pharmacologically detectable levels of the drug in biological samples and this knowledge advances our understanding and future application of the oral nicotine model." @default.
- W2186725344 created "2016-06-24" @default.
- W2186725344 creator A5017308029 @default.
- W2186725344 creator A5057196150 @default.
- W2186725344 creator A5073236677 @default.
- W2186725344 date "2008-01-01" @default.
- W2186725344 modified "2023-09-24" @default.
- W2186725344 title "Voluntary Consumption of Concentrated Oral Nicotine Solutions and Serum Nicotine Detection by GC-MS" @default.
- W2186725344 cites W100044276 @default.
- W2186725344 cites W1480121462 @default.
- W2186725344 cites W1877417792 @default.
- W2186725344 cites W1967737552 @default.
- W2186725344 cites W1969176202 @default.
- W2186725344 cites W1987157982 @default.
- W2186725344 cites W1988163743 @default.
- W2186725344 cites W2004281762 @default.
- W2186725344 cites W2004450098 @default.
- W2186725344 cites W2010485488 @default.
- W2186725344 cites W2015898814 @default.
- W2186725344 cites W2015899172 @default.
- W2186725344 cites W2029012843 @default.
- W2186725344 cites W2031685652 @default.
- W2186725344 cites W2035988756 @default.
- W2186725344 cites W2039094655 @default.
- W2186725344 cites W2049160507 @default.
- W2186725344 cites W2051268821 @default.
- W2186725344 cites W2053868358 @default.
- W2186725344 cites W2054553551 @default.
- W2186725344 cites W2071693138 @default.
- W2186725344 cites W2073025347 @default.
- W2186725344 cites W2075742395 @default.
- W2186725344 cites W2095297630 @default.
- W2186725344 cites W2097163830 @default.
- W2186725344 cites W2098805226 @default.
- W2186725344 cites W2110592678 @default.
- W2186725344 cites W2111774807 @default.
- W2186725344 cites W2117939256 @default.
- W2186725344 cites W2125237084 @default.
- W2186725344 cites W2153312853 @default.
- W2186725344 cites W2153752506 @default.
- W2186725344 cites W2321756620 @default.
- W2186725344 cites W2342390471 @default.
- W2186725344 cites W2412751556 @default.
- W2186725344 cites W2466087406 @default.
- W2186725344 cites W2767055761 @default.
- W2186725344 hasPublicationYear "2008" @default.
- W2186725344 type Work @default.
- W2186725344 sameAs 2186725344 @default.
- W2186725344 citedByCount "1" @default.
- W2186725344 countsByYear W21867253442020 @default.
- W2186725344 crossrefType "journal-article" @default.
- W2186725344 hasAuthorship W2186725344A5017308029 @default.
- W2186725344 hasAuthorship W2186725344A5057196150 @default.
- W2186725344 hasAuthorship W2186725344A5073236677 @default.
- W2186725344 hasConcept C126322002 @default.
- W2186725344 hasConcept C162356407 @default.
- W2186725344 hasConcept C185592680 @default.
- W2186725344 hasConcept C205345274 @default.
- W2186725344 hasConcept C2776319443 @default.
- W2186725344 hasConcept C2777056448 @default.
- W2186725344 hasConcept C2777477808 @default.
- W2186725344 hasConcept C2779547902 @default.
- W2186725344 hasConcept C42407357 @default.
- W2186725344 hasConcept C43617362 @default.
- W2186725344 hasConcept C71924100 @default.
- W2186725344 hasConcept C98274493 @default.
- W2186725344 hasConceptScore W2186725344C126322002 @default.
- W2186725344 hasConceptScore W2186725344C162356407 @default.
- W2186725344 hasConceptScore W2186725344C185592680 @default.
- W2186725344 hasConceptScore W2186725344C205345274 @default.
- W2186725344 hasConceptScore W2186725344C2776319443 @default.
- W2186725344 hasConceptScore W2186725344C2777056448 @default.
- W2186725344 hasConceptScore W2186725344C2777477808 @default.
- W2186725344 hasConceptScore W2186725344C2779547902 @default.
- W2186725344 hasConceptScore W2186725344C42407357 @default.
- W2186725344 hasConceptScore W2186725344C43617362 @default.
- W2186725344 hasConceptScore W2186725344C71924100 @default.
- W2186725344 hasConceptScore W2186725344C98274493 @default.
- W2186725344 hasLocation W21867253441 @default.
- W2186725344 hasOpenAccess W2186725344 @default.
- W2186725344 hasPrimaryLocation W21867253441 @default.
- W2186725344 hasRelatedWork W1771836943 @default.
- W2186725344 hasRelatedWork W1973269259 @default.
- W2186725344 hasRelatedWork W1977968245 @default.
- W2186725344 hasRelatedWork W1998601349 @default.
- W2186725344 hasRelatedWork W2027147073 @default.
- W2186725344 hasRelatedWork W2040952485 @default.
- W2186725344 hasRelatedWork W2044833842 @default.
- W2186725344 hasRelatedWork W2054457544 @default.
- W2186725344 hasRelatedWork W2097496898 @default.
- W2186725344 hasRelatedWork W2105865249 @default.
- W2186725344 hasRelatedWork W2106550672 @default.
- W2186725344 hasRelatedWork W2169404134 @default.
- W2186725344 hasRelatedWork W2417011051 @default.
- W2186725344 hasRelatedWork W2517991072 @default.
- W2186725344 hasRelatedWork W2524632167 @default.
- W2186725344 hasRelatedWork W2769714482 @default.
- W2186725344 hasRelatedWork W2911888174 @default.
- W2186725344 hasRelatedWork W2941434020 @default.
- W2186725344 hasRelatedWork W2997320676 @default.