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• W2186766099 abstract "ABSTRACT Objective: To investigate the immunohistochemical expressions of p53, ki67, CK20 in superficial papillary urothelial neoplasms ofthe bladder and correlate them with histologic grade, tumor progression and recurrence. Methods: We selected samples of 43patients with superficial transitional cell carcinoma of the bladder. They were divided into two groups, one called Recurrent (R), with18 individuals, and other Non-Recurrent (NR), with 25. Multi-sampling blocks were prepared. The immunohistochemical techniqueemployed was immunoperoxidase, and the antibodies were: p53: Novocastra (clone DO7) at a dilution of 1/100; Ki67: Spring (cloneSP6) at a dilution of 1/100; and CK20: Dako (clone K20 .8) at a dilution of 1/50. Results: The expression of p53 was observed in 11cases, six in the Recurrent group and five in the Non-Recurrent, all high-grade tumors (p = 0.0001). The histologic progressionoccurred in six patients (p = 0.0076). Of the 18 Recurrent cases, six showed immunoreactivity for p53 and 12 were negative for thisantibody (p = 0.1715). Ki67 was positive in 17 of the 18 cases from the Recurrent group (p = 0.0001) and, from 20 high-grade tumors,18 showed reaction to this antibody (p = 0.0001). Of the 18 individuals who had recurrence, 13 showed anomalous expression forCK20 (p = 0.0166). In high-grade carcinomas, of the 20 cases, 16 showed anomalous expression for this antibody, while 18 of the 23patients with low-grade tumors showed normal expression for CK20 (p = 0.0002). Conclusion: The p53 showed good correlationwith histologic progression and histologic grade. Ki67 was strongly associated with recurrence and histologic grade, and CK20 wasalso associated with these variables.Key words: Urinary bladder. Neoplasms. Urinary bladder neoplasms. Immunohistochemistry. Biological makers.From the Postgraduate Program in Principles of Surgery, Evangelical Faculty of Parana / Evangelical University Hospital of Curitiba / MedicalResearch Institute, Curitiba, Parana State – PR, Brazil.1. Master’s Degree, Postgraduate Program in Principles of Surgery, Medical Research Institute, Evangelical Faculty of Parana / EvangelicalUniversity Hospital of Curitiba; 2. PhD, Permanent Professor, Postgraduate Program in Principles of Surgery, Medical Research Institute,Evangelical Faculty of Parana / Coordinator, Service of Metabolic and Bariatric Surgery, Evangelical University Hospital of Curitiba; 3. PhD,Urologist, Marieta Konder Bornhausen Hospital and Maternity. Itajai; 4. Assistant Professor, Evangelical Faculty of Parana; 5. UndergraduateResearch Scholarship Grantee, Evangelical Faculty of Parana / Evangelical Hospital of Curitiba." @default.
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• W2186766099 date "2012-01-01" @default.
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• W2186766099 title "Superficial papillary urothelial neoplasms of the bladder" @default.
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