Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186768160> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2186768160 abstract "A study was conducted to provide a theoretical basis and clinical dosage regimen for using Florfenicol (FFC) to prevent Contagious Caprine Pleuropneumonia (CCPP) in goats. Twelve healthy goats were divided into two groups: Group A designated as the healthy, non-inoculated, control group and Group B designated as the CCPP treatment group. All goats were injected with a single dose of FFC at 20 mg/kg body weight intramuscularly (IM). Plasma concentrations of FFC and minimal inhibitory concentrations (MIC) of FFC on Mycoplasma sp. that causes CCPP were determined. Pharmacokinetic parameters were calculated by the 3P97 computer program. The results indicated that there was no obvious difference of pharmacokinetics of FFC in healthy goats and CCPP goats. The characteristics of pharmacokinetics of the IM injecting of FFC in all goats demonstrated fast absorption, broad distribution, effective concentration and slow elimination. Main parameters of the pharmacokinetics were as follows: T½Ka = 0.41 ± 0.25 h, T½ Ke = 7.41 ± 3.66 h, Tpeak = 1.57 ± 0.57 h, Cmax = 4.64±2.15 mg/l, Area under the concentration-time curve (AUC) = 54.38±20.65 mg/h/l. The MIC was 0.18 ± 0.07 μg/ml. A FFC clinical therapy scheme for goats diagnosed with CCPP is as follows: administration cycle (τ) = 24.21 h, first dose (X 0 ) = 21.20 mg/kg, maintaining dose (X) = 20 mg/kg, times of administration (n) when the ƒss reaches 99.9% = 2.38 Keyword: goats, Contagious Caprine Pleuropneumonia, Florfenicol, pharmacokinetics" @default.
- W2186768160 created "2016-06-24" @default.
- W2186768160 creator A5022601957 @default.
- W2186768160 creator A5027738048 @default.
- W2186768160 creator A5046361105 @default.
- W2186768160 creator A5089684709 @default.
- W2186768160 date "2011-01-01" @default.
- W2186768160 modified "2023-10-02" @default.
- W2186768160 title "Therapy Scheme and Pharmacokinetics of Injecting Florfenicol in Contagious Caprine Pleuropneumonia Goats" @default.
- W2186768160 cites W1612795536 @default.
- W2186768160 cites W1834264334 @default.
- W2186768160 cites W1964476599 @default.
- W2186768160 cites W1986318715 @default.
- W2186768160 cites W1993100146 @default.
- W2186768160 cites W2051478856 @default.
- W2186768160 cites W2321766366 @default.
- W2186768160 cites W2347838065 @default.
- W2186768160 hasPublicationYear "2011" @default.
- W2186768160 type Work @default.
- W2186768160 sameAs 2186768160 @default.
- W2186768160 citedByCount "0" @default.
- W2186768160 crossrefType "journal-article" @default.
- W2186768160 hasAuthorship W2186768160A5022601957 @default.
- W2186768160 hasAuthorship W2186768160A5027738048 @default.
- W2186768160 hasAuthorship W2186768160A5046361105 @default.
- W2186768160 hasAuthorship W2186768160A5089684709 @default.
- W2186768160 hasConcept C112705442 @default.
- W2186768160 hasConcept C126322002 @default.
- W2186768160 hasConcept C140793950 @default.
- W2186768160 hasConcept C159047783 @default.
- W2186768160 hasConcept C22979827 @default.
- W2186768160 hasConcept C2778465605 @default.
- W2186768160 hasConcept C2780663544 @default.
- W2186768160 hasConcept C2781413609 @default.
- W2186768160 hasConcept C501593827 @default.
- W2186768160 hasConcept C71924100 @default.
- W2186768160 hasConcept C86803240 @default.
- W2186768160 hasConcept C89423630 @default.
- W2186768160 hasConcept C98274493 @default.
- W2186768160 hasConceptScore W2186768160C112705442 @default.
- W2186768160 hasConceptScore W2186768160C126322002 @default.
- W2186768160 hasConceptScore W2186768160C140793950 @default.
- W2186768160 hasConceptScore W2186768160C159047783 @default.
- W2186768160 hasConceptScore W2186768160C22979827 @default.
- W2186768160 hasConceptScore W2186768160C2778465605 @default.
- W2186768160 hasConceptScore W2186768160C2780663544 @default.
- W2186768160 hasConceptScore W2186768160C2781413609 @default.
- W2186768160 hasConceptScore W2186768160C501593827 @default.
- W2186768160 hasConceptScore W2186768160C71924100 @default.
- W2186768160 hasConceptScore W2186768160C86803240 @default.
- W2186768160 hasConceptScore W2186768160C89423630 @default.
- W2186768160 hasConceptScore W2186768160C98274493 @default.
- W2186768160 hasLocation W21867681601 @default.
- W2186768160 hasOpenAccess W2186768160 @default.
- W2186768160 hasPrimaryLocation W21867681601 @default.
- W2186768160 hasRelatedWork W123345521 @default.
- W2186768160 hasRelatedWork W1516618083 @default.
- W2186768160 hasRelatedWork W1939594390 @default.
- W2186768160 hasRelatedWork W1966016921 @default.
- W2186768160 hasRelatedWork W1970928935 @default.
- W2186768160 hasRelatedWork W2011708730 @default.
- W2186768160 hasRelatedWork W2077283981 @default.
- W2186768160 hasRelatedWork W2088266208 @default.
- W2186768160 hasRelatedWork W2123363151 @default.
- W2186768160 hasRelatedWork W21404597 @default.
- W2186768160 hasRelatedWork W2187087389 @default.
- W2186768160 hasRelatedWork W2356650754 @default.
- W2186768160 hasRelatedWork W2357670862 @default.
- W2186768160 hasRelatedWork W2366348207 @default.
- W2186768160 hasRelatedWork W2421646221 @default.
- W2186768160 hasRelatedWork W2776386134 @default.
- W2186768160 hasRelatedWork W3092416482 @default.
- W2186768160 hasRelatedWork W3156858755 @default.
- W2186768160 hasRelatedWork W2136683508 @default.
- W2186768160 hasRelatedWork W2998363045 @default.
- W2186768160 isParatext "false" @default.
- W2186768160 isRetracted "false" @default.
- W2186768160 magId "2186768160" @default.
- W2186768160 workType "article" @default.