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- W2186791808 abstract "Summary Cinnamomum zeylanicum (Lauraceae) bark is generally used in Cameroon ethnomedicine for the treatment of cardiovascular diseases. Intravenous (i.v) injection of the ethanol extract resulted in a biphasic dose-related hypotensive activity. In normotensive rats (NTR), C. zeylanicum at the doses of 5, 10 and 20 mg/kg decreased systolic blood pressure (SBP) an hour after administration by 10.51 %, 17.55 % and 19.06 %, respectively. In salt-loaded hypertensive rats (SLHR), the decrease in systolic blood pressure was 13.10 %, 20.87 %, and 30.54 % at the above doses, respectively. This late hypotensive effects might be due to the reduction of peripheral resistance. In order to verify this hypothesis, the extract was assayed for its vasorelaxant activity. The results showed a vasorelaxant effect of C. zeylanicum on the rat thoracic aortic ring segments with (+E) or without (-E) endothelium precontracted with KCl (60 mM), suggesting that, C. zeylanicum might be inhibiting extracellular Ca² + through L-type voltage-sensitive channels. These findings suggest that C. zeylanicum exhibited it first hypotensive effect probably by reducing cardiac activity and secondly through vasodilation." @default.
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- W2186791808 date "2007-01-01" @default.
- W2186791808 modified "2023-10-17" @default.
- W2186791808 title "BLOOD PRESSURE LOWERING EFFECT OF THE ETHANOL EXTRACT FROM THE STEMBARK OF CINNAMOMUM ZEYLANICUM (LAURACEAE) IN RATS" @default.
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