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- W2186804575 abstract "SUMMARY A 12yearoldgirl withFriedreich's ataxia, inwhomprogression fromchemical to severeinsulin-dependent diabetes mellitus occurred overa twoyearperiod, ispresented. During the phaseofsubclinical diabetes herplasmaimmunoreactive insulin responsetooralglucose was markedly increased, butwhenshebecamesymptomatic grossinsulin deficiency hadsupervened. Thisreportdrawsattention totheunusual disorders ofcarbohydrate metabolism andinsulin secretion that may occurina variety ofneurological conditions. Although thedevelopment ofdiabetes mellitus inpatients withFriedreich's ataxia (FA)iswell described (Hewer andRobinson, 1968; Podolsky andSheremata, 1970), theconnection between thetwodiseases remains obscure. Thediabetic state inFA may,early on,resemble that seenin ataxia telangiectasia, wherecarbohydrate intolerance isaccompanied bymarkedhyperinsulinaemia (Joffe, Segal, andKeller, 1970; Schalch, McFarlin, andBarlow, 1970). We have followed apatient withFA inwhomprogression fromchemical to severe insulin-dependent diabetes occurred overa twoyearperiod." @default.
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- W2186804575 date "1973-01-01" @default.
- W2186804575 modified "2023-09-24" @default.
- W2186804575 title "Evolution ofdiabetes mellitus ina caseof Friedreich's ataxia" @default.
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