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• W2186823009 endingPage "3714" @default.
• W2186823009 startingPage "3703" @default.
• W2186823009 abstract "We present evidence that hedgehog (hh) protein secreted by posterior compartment cells plays a key role in patterning the posterior portion of the anterior compartment in adult abdominal segments. Loss of function of hh in the hh(ts2) mutant causes the loss of posterior tergite characteristics in the anterior compartment, whereas ectopic expression driven by hs-hh or the gain-of-function allele hh(Mir) causes transformation of anterior structures toward the posterior. FLP-out hh-expressing clones in the anterior compartment induce surrounding wild-type cells to produce posterior tergite structures, establishing that hh functions nonautonomously. The effects of pulses of ectopic expression driven by hs-hh indicate that bristle type and pigmentation are patterned by hh at widely different times in pupal development. We also present evidence that the primary polarization of abdominal segments is symmetric. This symmetry is strikingly revealed by ectopic expression of engrailed (en). As expected, this transforms anterior compartment cells to posterior compartment identity. In addition, however, ectopic en expression causes an autonomous reversal of polarity in the anterior portion of the anterior compartment, but not the posterior portion. By determining the position of polarity reversal within en-expressing clones, we were able to define a cryptic line of symmetry that lies within the pigment band of the normal tergite. This line appears to be retained in hh(ts2) mutants raised at the restrictive temperature, suggesting it is not established by hh signaling. We argue that the primary role of hh in controlling polarity is to cause anterior compartment cells to reverse their interpretation of an underlying symmetric polarization. Consistent with this, we find that strong ectopic expression of hh causes mirror-symmetric double posterior patterning, whereas hh loss of function can cause mirror-symmetric double anterior patterning." @default.
• W2186823009 created "2016-06-24" @default.
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• W2186823009 date "1997-10-01" @default.
• W2186823009 modified "2023-10-14" @default.
• W2186823009 title "The roles of <i>hedgehog</i> and <i>engrailed</i> in patterning adult abdominal segments of <i>Drosophila</i>" @default.
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• W2186823009 doi "https://doi.org/10.1242/dev.124.19.3703" @default.
• W2186823009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9367426" @default.
• W2186823009 hasPublicationYear "1997" @default.
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