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• W2186824693 abstract "Decreased cell function in aged and photo damaged skin appears to be due to abnormalities in the signaling pathways that regulate matrix production. In human dermal fibroblasts, TGF-β not only functions as primary stimulus for collagen synthesis, but also reduced collagen degradation by inhibiting MMP-1 expression. Our studies were designed in order to define the fibroblasts proliferative status and molecular basis for changes in collagen homeostasis, induced by three phytocompounds, derivatives from triterpenic acids. The screening techniques we used are beads - based flow cytometry assay for the quantization of soluble proteins (TGF- β), collagen synthesis and Matrixmetaloproteinases (MMP) expression, cell cycle dynamics and successive proliferative generations' determination after fluorescent staining with propidium iodide (PI) and carboxy fluorescein diacetat succin imidil ester (CFSE). All three compounds stimulate fibroblasts proliferation, but their action on TGF- β cytosolic release is different: the glicosidate form of the phytocompound decrease this cytokine secretion and activate the metalloproteinase action as a consequence, but the other compounds stimulate TGF- β, having significant impact on matrix proteins relief. The therapeutic targets of the three compounds are: wound healing (matrix remodeling action, controlling fibrosis), catalysts of structural proteins synthesis, important in chronological ageing." @default.
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• W2186824693 date "2013-01-01" @default.
• W2186824693 modified "2023-09-26" @default.
• W2186824693 title "TGF-β modulation by natural active compounds from S. officinalis and C. officinalis" @default.
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