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- W2186854718 abstract "Introductioncan be categorized based on their chemical structure, including: betalactams, aminoglycosides, tetracyclines, fluoroquinolines, macrolides, and polyether ionophores. The use of polyether ionophorous antibiotics (monensin, salinomycin, lasolacid A, and narasin) in industrial agriculture is significant, with over 3,700,000 kg approved for use in 2009 by the Food & Drug Administration. 1 Ionophores are approved feed additives, and are used to a large extent in the poultry and beef production industry to control and prevent coccidiosis disease. Adding these ionophores to animal feeds can improve growth rates, but there is concern that antibiotic residues may remain in tissues, food products, and the environment. Some animals such as horses, 2 certain avian species, 3,4 dogs, 5 and cats 6 are especially sensitive to ionophore toxicity. Thus, there is a need for sensitive methods for their analysis. These antibiotics originate from natural sources and possess a weak chromophore, which make them difficult to analyze. Current HPLC-UV methods require the use of post-column derivatization with a methanolic, sulphuric acid vanillin reagent and heating to form a derivative that has a UV response. This not only increases system complexity but also reduces the peak resolution and sensitivity.7 Newer analytical" @default.
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- W2186854718 date "2012-01-01" @default.
- W2186854718 modified "2023-09-24" @default.
- W2186854718 title "A New Approach to the Simultaneous Analysis of Underivatized Ionophoric Antibiotics using Liquid Chromatography with Charged Aerosol Detection" @default.
- W2186854718 hasPublicationYear "2012" @default.
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