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• W2186885247 abstract "MnCl2 and dithiothreitol (DTT) enhance the adhesive functions of 1�2-rntegr'ns. We have used these agents and flow cytometry to distinguish the contributions of 1-�2-rntegrrns and L-selectin to neu- trophil aggregation. Although neither compound in- duced aggregation, they prolonged N-formyl- methionyl-leucyl-phenylalanine-induced aggrega- tion and produced larger aggregates. Because acti- vated polymorphonuclear granulocytes (PMN) shed L-selectin in the presence of MnCl2, but not DTT, we could evaluate the role of L-selectin in the early and late stages of aggregation. Blocking L-selectin sites with DREG200 Fab and/or 1�2-rntegrm sites with IB4 Fab indicated that aggregation under all conditions remained 1�2-rntegrin- and L-selectin-dependent. Disaggregation was integrin-dependent whether L- selectin was present or shed. The disaggregation kinetics suggested that integrin bonds turned over at a slower rate in MnC12-treated cells. Enhanced ag- gregation due to DTT and MnCl2 required sustained energy output, suggesting intracellular rather than strictly conformational control. These results pro- vide evidence that PMN aggregation, like leukocyte- endothelial cell adhesion, utilizes L-selectin to form intercellular contacts that are maintained through activated integrins. J. Leukoc. Riot. 60: 356-364; 1996." @default.
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• W2186885247 date "1996-01-01" @default.
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• W2186885247 title "DTT differentiates the roles of L-selectin and 32-integrins" @default.
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