Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186919798> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2186919798 abstract "Background- Recruitment of inflammatory cells inthelungsmay contribute to tissueinjury as a result of mediators released fromthese cells. Interleukin1p(IL-1,) isa potentinducer of neutrophil accumulation, a processthat may require localprotein biosynthesis. Macrophageinflammatory protein2 (MIP-2)isa - 6kD heparinbinding protein andisa memberoftheC-X-C superfamily thatcausessignificant neutrophil chemotaxis andactivation invitro. A studywas performedto determine whether IL-lp couldinduce theexpression ofMIP-2inthelungsofBrown-Norway rats. Methods-rhIL-lB (500U)or09% NaCl wasinjected intratracheally andbronchoalveolar lavage(BAL)cellsand lung tissues wereevaluated forMIP-2mRNA expression after RNA extraction byNorthernblotanalysis. MIP-2probewaspreparedfromcDNA obtained by reverse transcriptase-polymerase chainreaction (RT-PCR)ofBAL cells obtained froma rattreated withlipopolysaccharide. Results -Therewasnodetectable MIP-2 mRNA inthelungsofcontrol ratsbuta markedenhancement oftheexpression at fourhourswithnoexpression at12hours andaslight expression at24hours. IL-1p induced asignificant influx ofneutrophils intoBAL fluid witha transient increase inmacrophages. Insituhybridisation of lungsusingMIP-2cDNA probelabelled withdigoxigenin showedexpression of MIP-2mRNA inairway mononuclear cells andairway epithelium atfourhoursafter IL-1p; at24hoursthesignal hadnearly gone. Conclusion -IL-1p induces theexpression ofMIP-2mRNA inratlung. MIP-2may beonechemokine thatcouldcontribute to IL-1p inducedneutrophil influx. (Thorax 1995;50:1136-1140)" @default.
- W2186919798 created "2016-06-24" @default.
- W2186919798 creator A5007296904 @default.
- W2186919798 creator A5082485844 @default.
- W2186919798 date "1995-01-01" @default.
- W2186919798 modified "2023-09-26" @default.
- W2186919798 title "Induction ofmacrophage inflammatory protein 2 gene expression byinterleukin 1finratlung" @default.
- W2186919798 cites W1979585315 @default.
- W2186919798 cites W2134812217 @default.
- W2186919798 hasPublicationYear "1995" @default.
- W2186919798 type Work @default.
- W2186919798 sameAs 2186919798 @default.
- W2186919798 citedByCount "0" @default.
- W2186919798 crossrefType "journal-article" @default.
- W2186919798 hasAuthorship W2186919798A5007296904 @default.
- W2186919798 hasAuthorship W2186919798A5082485844 @default.
- W2186919798 hasConcept C104317684 @default.
- W2186919798 hasConcept C105580179 @default.
- W2186919798 hasConcept C137061746 @default.
- W2186919798 hasConcept C150194340 @default.
- W2186919798 hasConcept C153911025 @default.
- W2186919798 hasConcept C170493617 @default.
- W2186919798 hasConcept C185592680 @default.
- W2186919798 hasConcept C202751555 @default.
- W2186919798 hasConcept C203014093 @default.
- W2186919798 hasConcept C54166955 @default.
- W2186919798 hasConcept C55493867 @default.
- W2186919798 hasConcept C86803240 @default.
- W2186919798 hasConceptScore W2186919798C104317684 @default.
- W2186919798 hasConceptScore W2186919798C105580179 @default.
- W2186919798 hasConceptScore W2186919798C137061746 @default.
- W2186919798 hasConceptScore W2186919798C150194340 @default.
- W2186919798 hasConceptScore W2186919798C153911025 @default.
- W2186919798 hasConceptScore W2186919798C170493617 @default.
- W2186919798 hasConceptScore W2186919798C185592680 @default.
- W2186919798 hasConceptScore W2186919798C202751555 @default.
- W2186919798 hasConceptScore W2186919798C203014093 @default.
- W2186919798 hasConceptScore W2186919798C54166955 @default.
- W2186919798 hasConceptScore W2186919798C55493867 @default.
- W2186919798 hasConceptScore W2186919798C86803240 @default.
- W2186919798 hasLocation W21869197981 @default.
- W2186919798 hasOpenAccess W2186919798 @default.
- W2186919798 hasPrimaryLocation W21869197981 @default.
- W2186919798 hasRelatedWork W1496078232 @default.
- W2186919798 hasRelatedWork W1573746155 @default.
- W2186919798 hasRelatedWork W1763786736 @default.
- W2186919798 hasRelatedWork W1916213760 @default.
- W2186919798 hasRelatedWork W1924127518 @default.
- W2186919798 hasRelatedWork W1964094256 @default.
- W2186919798 hasRelatedWork W1977383371 @default.
- W2186919798 hasRelatedWork W2014832664 @default.
- W2186919798 hasRelatedWork W2059260742 @default.
- W2186919798 hasRelatedWork W2079809096 @default.
- W2186919798 hasRelatedWork W2082212691 @default.
- W2186919798 hasRelatedWork W2159693101 @default.
- W2186919798 hasRelatedWork W2168755282 @default.
- W2186919798 hasRelatedWork W2262747944 @default.
- W2186919798 hasRelatedWork W2389984145 @default.
- W2186919798 hasRelatedWork W2399110003 @default.
- W2186919798 hasRelatedWork W2414674520 @default.
- W2186919798 hasRelatedWork W3176086190 @default.
- W2186919798 hasRelatedWork W2513458195 @default.
- W2186919798 hasRelatedWork W2738180721 @default.
- W2186919798 isParatext "false" @default.
- W2186919798 isRetracted "false" @default.
- W2186919798 magId "2186919798" @default.
- W2186919798 workType "article" @default.