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- W2186957273 abstract "The nucleotide binding oligomerization domain 1 (NOD1) is a cytoplasmic pattern recognition receptor (PRR), and is a member of the NOD-like receptor (NLR) family. It senses various pathogens or their products, and plays an important role in inducing innate immunity. This report describes the identification of NOD1 and its down-stream signaling in the Indian major carp, catla (Catla catla), one of the highly commercially important and extensively cultured freshwater fish species in the Indian subcontinent. The basal expressions of NOD1and its downstream signaling molecule RICK (receptor interacting serine-threonine kinase) were analyzed in gill, liver, kidney, intestine, heart, spleen, brain, eye, muscle, skin and blood of healthy catla fingerlings by quantitative real-time PCR (qRT-PCR) assay, and it showed their wide expression in all tested tissues. Among the tested tissues, highest expression of NOD1 was observed in liver, and RICK in gill. Stimulation with iEDAP, LPS and poly I:C activated NOD1 receptor signaling resulting in significant (p < 0.05) induction of downstream signaling molecule RICK, and the effector molecules IL-1� in the treated fish group as compared to their control. Infection with Aeromonas hydrophila also activated NOD1 receptors signaling. These findings suggest the important role of NOD1 receptor as innate immune gene in fish." @default.
- W2186957273 created "2016-06-24" @default.
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- W2186957273 date "2013-01-01" @default.
- W2186957273 modified "2023-09-24" @default.
- W2186957273 title "Nucleotide Binding and Oligomerization Domain 1 (NOD1) Receptor in Catla ( Catla catla ) : Inductive Expression and Down-Stream Signaling in Ligand Stimulation and Bacterial Infections" @default.
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