FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2186985194> ?p ?o ?g. }

• W2186985194 abstract "The alkylating agent temozolomide, commonly used in the treatment of malignant glioma, causes cellular cytotoxicity by forming O 6 -methylguanine adducts. In this report, we investigated whether temozolomide alters the activity of the transcription factor nuclear factor-KB (NF-KB). Temozolomide inhibits basal and tumor necrosis factor A (TNFA)–induced NF-KB transcriptional activity without altering phosphorylation or degradation of inhibitor of KB-A. Inhibition of NF-K Bi s secondary to attenuation of p65 DNA binding, not nuclear translocation. Inhibition of DNA binding is shown both in vitro, with gel shift studies and DNA binding assays, and in vivo at KB sites. Consistent with inhibition of NF-KB activity, temozolomide reduces basal and TNFA-induced KB-dependent gene expression. Temozolomide also inhibits NF-KB activated by inducers other than TNFA, including lipopolysaccharide, doxorubicin, and phorbol 12-myristate 13-acetate. The inhibitory action of temozolomide on NF-KB is observed to be maximal following pretreatment of cells with temozolomide for 16 h and is also seen with the SN1-type methylating agent methylnitrosourea. The ability of temozolomide to form O 6 -methylguanine adducts is important for inhibition of NF-KB as is the presence of a functioning mismatch repair system. Activation of NF-KB with TNFA before administration of temozolomide reduces the cytotoxicity of temozolomide, whereas 16-h pretreatment with temozolomide resensitizes cells to killing. This work shows a mechanism whereby O 6 -methylguanine adducts formed by temozolomide lead to inhibition of NF-KB activity and illustrates a link between mismatch repair processing of alkylator-induced DNA damage and cell death. [Cancer Res 2007;67(14):6889–98]" @default.
• W2186985194 created "2016-06-24" @default.
• W2186985194 creator A5032984193 @default.
• W2186985194 creator A5049402683 @default.
• W2186985194 creator A5054855052 @default.
• W2186985194 creator A5056075309 @default.
• W2186985194 creator A5057135590 @default.
• W2186985194 creator A5067054634 @default.
• W2186985194 date "2007-01-01" @default.
• W2186985194 modified "2023-09-27" @default.
• W2186985194 title "Inhibition of Nuclear Factor-KB Activity by Temozolomide Involves O 6 -Methylguanine-Induced Inhibition of p65DNA Binding" @default.
• W2186985194 cites W1485886034 @default.
• W2186985194 cites W1493267183 @default.
• W2186985194 cites W1525505117 @default.
• W2186985194 cites W1537425172 @default.
• W2186985194 cites W1591240858 @default.
• W2186985194 cites W1636514590 @default.
• W2186985194 cites W1864544636 @default.
• W2186985194 cites W1921281342 @default.
• W2186985194 cites W1968209863 @default.
• W2186985194 cites W1968601707 @default.
• W2186985194 cites W1975608733 @default.
• W2186985194 cites W1977177262 @default.
• W2186985194 cites W1978429511 @default.
• W2186985194 cites W1979520139 @default.
• W2186985194 cites W1980195588 @default.
• W2186985194 cites W1985304309 @default.
• W2186985194 cites W1988299559 @default.
• W2186985194 cites W1992267182 @default.
• W2186985194 cites W1995505431 @default.
• W2186985194 cites W1995755857 @default.
• W2186985194 cites W1996627105 @default.
• W2186985194 cites W1997349871 @default.
• W2186985194 cites W2018711510 @default.
• W2186985194 cites W2024964682 @default.
• W2186985194 cites W2043892945 @default.
• W2186985194 cites W2049428247 @default.
• W2186985194 cites W2051994734 @default.
• W2186985194 cites W2055878807 @default.
• W2186985194 cites W2061880574 @default.
• W2186985194 cites W2076141569 @default.
• W2186985194 cites W2079457084 @default.
• W2186985194 cites W2080028600 @default.
• W2186985194 cites W2087855240 @default.
• W2186985194 cites W2096287682 @default.
• W2186985194 cites W2099789202 @default.
• W2186985194 cites W2106877484 @default.
• W2186985194 cites W2110440735 @default.
• W2186985194 cites W2111558295 @default.
• W2186985194 cites W2116116912 @default.
• W2186985194 cites W2121001769 @default.
• W2186985194 cites W2133638941 @default.
• W2186985194 cites W2143976980 @default.
• W2186985194 cites W2166382251 @default.
• W2186985194 cites W2166932692 @default.
• W2186985194 cites W2167151663 @default.
• W2186985194 cites W2167713837 @default.
• W2186985194 cites W2172132727 @default.
• W2186985194 hasPublicationYear "2007" @default.
• W2186985194 type Work @default.
• W2186985194 sameAs 2186985194 @default.
• W2186985194 citedByCount "0" @default.
• W2186985194 crossrefType "journal-article" @default.
• W2186985194 hasAuthorship W2186985194A5032984193 @default.
• W2186985194 hasAuthorship W2186985194A5049402683 @default.
• W2186985194 hasAuthorship W2186985194A5054855052 @default.
• W2186985194 hasAuthorship W2186985194A5056075309 @default.
• W2186985194 hasAuthorship W2186985194A5057135590 @default.
• W2186985194 hasAuthorship W2186985194A5067054634 @default.
• W2186985194 hasConcept C104317684 @default.
• W2186985194 hasConcept C109316439 @default.
• W2186985194 hasConcept C11960822 @default.
• W2186985194 hasConcept C153911025 @default.
• W2186985194 hasConcept C185592680 @default.
• W2186985194 hasConcept C195794163 @default.
• W2186985194 hasConcept C202751555 @default.
• W2186985194 hasConcept C2777389519 @default.
• W2186985194 hasConcept C2778227246 @default.
• W2186985194 hasConcept C2779527866 @default.
• W2186985194 hasConcept C2780043322 @default.
• W2186985194 hasConcept C33288867 @default.
• W2186985194 hasConcept C502942594 @default.
• W2186985194 hasConcept C552990157 @default.
• W2186985194 hasConcept C55493867 @default.
• W2186985194 hasConcept C86339819 @default.
• W2186985194 hasConcept C86803240 @default.
• W2186985194 hasConcept C91965660 @default.
• W2186985194 hasConcept C98274493 @default.
• W2186985194 hasConceptScore W2186985194C104317684 @default.
• W2186985194 hasConceptScore W2186985194C109316439 @default.
• W2186985194 hasConceptScore W2186985194C11960822 @default.
• W2186985194 hasConceptScore W2186985194C153911025 @default.
• W2186985194 hasConceptScore W2186985194C185592680 @default.
• W2186985194 hasConceptScore W2186985194C195794163 @default.
• W2186985194 hasConceptScore W2186985194C202751555 @default.
• W2186985194 hasConceptScore W2186985194C2777389519 @default.
• W2186985194 hasConceptScore W2186985194C2778227246 @default.
• W2186985194 hasConceptScore W2186985194C2779527866 @default.
• W2186985194 hasConceptScore W2186985194C2780043322 @default.
• W2186985194 hasConceptScore W2186985194C33288867 @default.

• next