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- W2186989700 abstract "function; andapproaches for correcting the progressive neurodegeneration that isa part of this syndrome.Ataxia-telangiectasia is an autosomal recessive disorder character-ized by neurodegeneration, immunodeficiency, hypogonadism andsusceptibility to cancer. At the cellular level, it is marked by genomicinstability, which is due to a defective response to double-strandedbreaks (DSBs) in DNA. This is manifested by hypersensitivity to ioniz-ing radiation (IR) and radiomimetic compounds, and by a decreasedability to activate the DNA-damage-response network, whichincludes the cell-cycle checkpoints (Lavin & Shiloh, 1997; Chun &Gatti, 2004). The protein product of the" @default.
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- W2186989700 date "2006-01-01" @default.
- W2186989700 modified "2023-09-23" @default.
- W2186989700 title "meeting report ATM and the DNA damage response Workshop on Ataxia-Telangiectasia and Related Syndromes" @default.
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