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• W2186998521 abstract "More than 20 years after the discovery of the HCV, it is now well established that HCV is of global importance affecting all countries, leading to a major global health problem tha t requires widespread active interventions for its prevention and control. Chronic hepatitis C was linked to the development of cirrhosis and hepatocellular carcinoma (HCC) in many areas of the world. WHO reported that Egypt has the highest prevalence (22% ) in the world which explained by the past practice of parenteral therapy for schistosomiasis. T cells that produce IL - 17 have recently been identified as a third distinct subset of effector T cells, and emerging data implicate Th17 cells as important in t he pathogenesis of chronic hepatitis C infection by regulating innate and adaptive immunity, including autoimmunity .So the present study was conducted to determine the role of IL - 17, with its potent pro - inflammatory properties, among chronic hepatitis C c ases with or without cirrhosis and HCC aimed at future immune - therapy. The study was conducted on 60 subjects with chronic hepatitis C infection before starting antiviral therapy; 20 chronic hepatitis C, 20 cirrhotic patients and 20 HCC HCV positive as wel l as 10 healthy subjects negative for HCV, HBV and HIV served as controls. IL - 17 was quantitated after mitogen stimulated whole peripheral venous blood by commercial enzyme linked immunosorbant assay ( ELISA ).Our results demonstrated a significant increa se in serum levels of IL - 17 among cirrhotic and HCC patients infected with HCV. While in chronic hepatitis C virus cases ,elevated IL - 17 values were non significant compared to controls. We can conclude that IL - 17 may play an important role in HCV immunopa thogenesis. It might be used as an indicator for cirrhosis and HCC as it promotes tumor growth by facilitating angiogenesis in tumor microenvironment. Also, its therapeutic application needs to be furtherly evaluated by in vivo studies in experimental anim als aiming at future immunotherapy." @default.
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• W2186998521 date "2012-01-01" @default.
• W2186998521 modified "2023-09-26" @default.
• W2186998521 title "Quantitative Estimation of Interleukin-17 in Patients with Chronic Liver Disorders" @default.
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