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• W2187017951 abstract "To evaluate the outcome of infants born to mothers with varicella zoster virus (VZV) infection in pregnancy who had second trimester amniocentesis for detection of placental transfer. We interviewed women who had had VZV infection in pregnancy and who underwent diagnostic amniocentesis to detect transplacental infection using both polymerase chain reaction (PCR) and cell culture methods to characterize their children’s clinical and psychomotor development. Twenty women who had a diagnosis of primary VZV during pregnancy were available for interview. The mean gestational age at which primary VZV was acquired was 11±3.5 weeks. One infant had hypospadias and developmental delay. He was born to an epileptic mother who had been treated during pregnancy with sodium valproate and clonazepam. Another infant had abnormal brainstem auditory-evoked potentials. All other infants were reported to have normal clinical and psychomotor development. In cases of varicella infection during pregnancy, negative studies of amniotic fluid using PCR may contribute to decision making. Évaluer l’issue des nouveau-nés issus de mères qui ont contracté une infection au virus varicelle-zona (VZV) pendant la grossesse et qui ont subi une amniocentèse au cours du deuxième trimestre aux fins de la détection du passage transplacentaire. Nous avons interviewé des femmes qui ont contracté une infection au VZV pendant la grossesse et qui ont subi une amniocentèse diagnostique visant à détecter une infection transplacentaire, en utilisant les méthodes de l’amplification en chaîne par polymérase (ACP) et de la culture cellulaire pour caractériser le développement clinique et psychomoteur de leurs enfants. Vingt femmes ayant obtenu un diagnostic d’infection primaire au VZV pendant la grossesse ont accepté de se prêter à une entrevue. L’âge gestationnel moyen auquel l’infection primaire au VZV a été contractée était de 11±3,5 semaines. Un nouveauné présentait un hypospadias et un retard du développement. Il était issu d’une mère épileptique qui avait fait l’objet d’un traitement au valproate de sodium et au clonazépam pendant la grossesse. Un autre nouveau-né présentait des potentiels évoqués auditifs du tronc cérébral anormaux. On a signalé que tous les autres nouveau-nés présentaient un développement clinique et psychomoteur normal. Dans les cas d’infection à la varicelle pendant la grossesse, les études négatives du liquide amniotique au moyen de l’ACP peuvent contribuer au processus décisionnel." @default.
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• W2187017951 date "2011-07-01" @default.
• W2187017951 modified "2023-10-07" @default.
• W2187017951 title "Fetal Outcome and Amniocentesis Results in Pregnancies Complicated by Varicella Infection" @default.
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• W2187017951 doi "https://doi.org/10.1016/s1701-2163(16)34957-x" @default.
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