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- W2187020003 abstract "Broderick TL, Nadeau A. Plasma free and esterified carnitine levels in the streptozotocin rat after a single bout of exercise. JEPonline 2006;9(3):17-23. Clinical diabetes is associated with disturbances in carnitine metabolism during exercise. In type 1 diabetic patients, the typical reduction in plasma free carnitine (FC) is absent during an acute session of exercise. To establish an experimental model of study, male Wistar rats were divided into a control (n=8) and a diabetic (n=8) group. Diabetes was induced with streptozotocin (STZ) at the dose of 50 mg/kg body weight. One week following the induction of diabetes, exercise was performed on a treadmill at 22 m/min for 60 min at an incline of 8°. Arterial blood was collected at rest and immediately following exercise in previously cannulated rats. In control rats, compared to rest, FC levels decreased significantly after 60 min of exercise. In diabetic rats, on the other hand, the decrease in FC levels was not observed after exercise. Plasma esterified carnitine levels increased in both groups postexercise, but this increase was non significant from resting levels. Our results indicate that the plasma FC response at the end of acute exercise in the STZ-model of diabetes is consistent with the observations in type 1 diabetic patients. This model may thus be suited to examine the disturbances in carnitine metabolism during exercise typically reported in diabetic patients." @default.
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- W2187020003 date "2006-01-01" @default.
- W2187020003 modified "2023-09-27" @default.
- W2187020003 title "PLASMA FREE AND ESTERIFIED CARNITINE LEVELS IN THE STREPTOZOTOCIN DIABETIC RAT AFTER A SINGLE BOUT OF EXERCISE" @default.
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