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• W2187029405 endingPage "429" @default.
• W2187029405 startingPage "397" @default.
• W2187029405 abstract "Family studies have revealed that individual variations in the levels and structures of lipoproteins in the blood are due in large part to hereditary influences. Since such lipoprotein variations are strongly associated with atherosclerosis, the major cause of heart disease and stroke, the characterization of these hereditary influences provides an opportunity to better understand the genetic components contributing to the disease. Many laboratories have now taken up this challenge (reviewed in ref. 1). The problem is a difficult one, since the lipoprotein variations clearly result from a large variety of hereditary as well as environmental factors. Atherosclerosis is undoubtedly even more complex and may, like cancer, have myriad causes. In this review approaches to the problem and the results obtained to date are discussed. The most powerful strategy involves combined genetic and biochemical studies of candidate genes - genes at which allelic variation is likely to affect lipoprotein phenotypes. Among such candidate genes, many of which have now been characterized, are those encoding apolipoproteins, lipoprotein receptors, and enzymes involved in lipid metabolism. This review focuses on relatively common genetic differences rather than rare mutations. Since animals provide useful models for the genetic control of lipoprotein metabolism, results from animal and human studies have been integrated. Metabolism" @default.
• W2187029405 created "2016-06-24" @default.
• W2187029405 creator A5024741961 @default.
• W2187029405 date "1988-04-01" @default.
• W2187029405 modified "2023-09-29" @default.
• W2187029405 title "Genetic factors affecting blood lipoproteins: the candidate gene approach." @default.
• W2187029405 cites W136685878 @default.
• W2187029405 cites W1485810221 @default.
• W2187029405 cites W1486193263 @default.
• W2187029405 cites W1486776518 @default.
• W2187029405 cites W1501416111 @default.
• W2187029405 cites W1504706920 @default.
• W2187029405 cites W1506571572 @default.
• W2187029405 cites W1507649645 @default.
• W2187029405 cites W1512279465 @default.
• W2187029405 cites W1517698792 @default.
• W2187029405 cites W1519900170 @default.
• W2187029405 cites W1521392480 @default.
• W2187029405 cites W1522648964 @default.
• W2187029405 cites W1524287153 @default.
• W2187029405 cites W1530399082 @default.
• W2187029405 cites W1532932107 @default.
• W2187029405 cites W1533930495 @default.
• W2187029405 cites W1537961425 @default.
• W2187029405 cites W1548593517 @default.
• W2187029405 cites W1551585156 @default.
• W2187029405 cites W1555373432 @default.
• W2187029405 cites W1556144574 @default.
• W2187029405 cites W1556944648 @default.
• W2187029405 cites W1569405015 @default.
• W2187029405 cites W1573416467 @default.
• W2187029405 cites W1575753161 @default.
• W2187029405 cites W1577502861 @default.
• W2187029405 cites W1580211147 @default.
• W2187029405 cites W1583703772 @default.
• W2187029405 cites W1595513249 @default.
• W2187029405 cites W1597911277 @default.
• W2187029405 cites W1601260221 @default.
• W2187029405 cites W1692442206 @default.
• W2187029405 cites W1729623267 @default.
• W2187029405 cites W1736154854 @default.
• W2187029405 cites W1933275042 @default.
• W2187029405 cites W1935855412 @default.
• W2187029405 cites W1952062893 @default.
• W2187029405 cites W1963518284 @default.
• W2187029405 cites W1964806623 @default.
• W2187029405 cites W1964829898 @default.
• W2187029405 cites W1964986765 @default.
• W2187029405 cites W1965027092 @default.
• W2187029405 cites W1965848933 @default.
• W2187029405 cites W1967378390 @default.
• W2187029405 cites W1967922312 @default.
• W2187029405 cites W1969299547 @default.
• W2187029405 cites W1970030019 @default.
• W2187029405 cites W1974002399 @default.
• W2187029405 cites W1976506211 @default.
• W2187029405 cites W1977359700 @default.
• W2187029405 cites W1978054324 @default.
• W2187029405 cites W1978952897 @default.
• W2187029405 cites W1982154337 @default.
• W2187029405 cites W1983271161 @default.
• W2187029405 cites W1984526861 @default.
• W2187029405 cites W1984725713 @default.
• W2187029405 cites W1985530443 @default.
• W2187029405 cites W1985686337 @default.
• W2187029405 cites W1986030167 @default.
• W2187029405 cites W1986167249 @default.
• W2187029405 cites W1986340013 @default.
• W2187029405 cites W1987157247 @default.
• W2187029405 cites W1988110915 @default.
• W2187029405 cites W1988386661 @default.
• W2187029405 cites W1988949856 @default.
• W2187029405 cites W1989364943 @default.
• W2187029405 cites W1989683929 @default.
• W2187029405 cites W1990170200 @default.
• W2187029405 cites W1990815703 @default.
• W2187029405 cites W1992481038 @default.
• W2187029405 cites W1993494932 @default.
• W2187029405 cites W1997045413 @default.
• W2187029405 cites W1997211091 @default.
• W2187029405 cites W1997905423 @default.
• W2187029405 cites W1998834140 @default.
• W2187029405 cites W1999333401 @default.
• W2187029405 cites W1999629767 @default.
• W2187029405 cites W1999794740 @default.
• W2187029405 cites W2000388833 @default.
• W2187029405 cites W2000991693 @default.
• W2187029405 cites W2002702884 @default.
• W2187029405 cites W2003577247 @default.
• W2187029405 cites W200362752 @default.
• W2187029405 cites W2004359169 @default.
• W2187029405 cites W2004549436 @default.
• W2187029405 cites W2005603078 @default.
• W2187029405 cites W2006557952 @default.
• W2187029405 cites W2007715864 @default.
• W2187029405 cites W2008485598 @default.
• W2187029405 cites W2008763733 @default.
• W2187029405 cites W2009075724 @default.

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