FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187053864> ?p ?o ?g. }

• W2187053864 endingPage "60" @default.
• W2187053864 startingPage "2453" @default.
• W2187053864 abstract "Retinoid-inducible gene I (RIG1) is a growth regulator protein that exhibits activities to suppress cellular growth and induce cellular differentiation and apoptosis. This study analyzed the expression and regulation of RIG1 in breast cancer cells in vitro and in vivo.Expression of RIG1 RNA in breast cancer tissues was analyzed using RNA in situ hybridization. Regulation of RIG1 expression by 17beta-estradiol (E2) was analyzed by semi-quantitative reverse transcription polymerase chain reaction.RIG1 expression in 47 breast cancer tissues was detected mostly in the cytoplasm and in some nuclei. Levels of both cytoplasmic and nuclear RIG1 mRNA were significantly lower in 20 estrogen receptor-positive (ER+) than in 27 ER-negative (ER-) tissues (p < 0.05), in 20 progesterone receptor-positive (PR+) than in 27 PR-negative (PR-) tissues (p < 0.01), and in 14 ER+/PR+ than in 21 ER-/PR-tissues (p < 0.05). Basal levels of RIG1 and ER mRNA were inversely related between ER+ (MCF-7 WS8 and ZR75-1) and ER- (ZR-75-30) breast cancer cells. E2 (1 nM) treatment for two days suppressed RIG1 mRNA levels in MCF-7 WS8 and ZR-75-1 cells, but not in the ER- ZR-75-30 cells. The E2-mediated down-regulation of RIG1 expression was time- and concentration-dependent in ZR-75-1 cells.The negative association between RIG1 and ER expression in breast cancer tissues and down-regulation of RIG1 by E2 in breast cancer cells in vitro suggest that RIG1 expression is negatively regulated by E2 through activation of the ER in ER+ breast cancer cells." @default.
• W2187053864 created "2016-06-24" @default.
• W2187053864 creator A5027310614 @default.
• W2187053864 creator A5031336785 @default.
• W2187053864 creator A5044484602 @default.
• W2187053864 creator A5053141524 @default.
• W2187053864 creator A5060571216 @default.
• W2187053864 creator A5072767524 @default.
• W2187053864 creator A5084600710 @default.
• W2187053864 date "2005-08-06" @default.
• W2187053864 modified "2023-09-26" @default.
• W2187053864 title "Expression and regulation of retinoid-inducible gene 1 (RIG1) in breast cancer." @default.
• W2187053864 cites W1564668797 @default.
• W2187053864 cites W1972592662 @default.
• W2187053864 cites W1973267030 @default.
• W2187053864 cites W1978100863 @default.
• W2187053864 cites W1978432350 @default.
• W2187053864 cites W1983969206 @default.
• W2187053864 cites W1997499199 @default.
• W2187053864 cites W1999426074 @default.
• W2187053864 cites W2011929910 @default.
• W2187053864 cites W2014222181 @default.
• W2187053864 cites W2019304928 @default.
• W2187053864 cites W2026140728 @default.
• W2187053864 cites W2029080892 @default.
• W2187053864 cites W2032021742 @default.
• W2187053864 cites W2034816211 @default.
• W2187053864 cites W2042670391 @default.
• W2187053864 cites W2054299455 @default.
• W2187053864 cites W2071068913 @default.
• W2187053864 cites W2081678865 @default.
• W2187053864 cites W2086861062 @default.
• W2187053864 cites W2091025792 @default.
• W2187053864 cites W2094591121 @default.
• W2187053864 cites W2102880496 @default.
• W2187053864 cites W2119438754 @default.
• W2187053864 cites W2132372682 @default.
• W2187053864 cites W2312392465 @default.
• W2187053864 cites W2397732781 @default.
• W2187053864 cites W2410361929 @default.
• W2187053864 cites W2413006478 @default.
• W2187053864 cites W591375881 @default.
• W2187053864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16080475" @default.
• W2187053864 hasPublicationYear "2005" @default.
• W2187053864 type Work @default.
• W2187053864 sameAs 2187053864 @default.
• W2187053864 citedByCount "11" @default.
• W2187053864 countsByYear W21870538642012 @default.
• W2187053864 countsByYear W21870538642014 @default.
• W2187053864 countsByYear W21870538642015 @default.
• W2187053864 countsByYear W21870538642016 @default.
• W2187053864 countsByYear W21870538642017 @default.
• W2187053864 countsByYear W21870538642020 @default.
• W2187053864 countsByYear W21870538642023 @default.
• W2187053864 crossrefType "journal-article" @default.
• W2187053864 hasAuthorship W2187053864A5027310614 @default.
• W2187053864 hasAuthorship W2187053864A5031336785 @default.
• W2187053864 hasAuthorship W2187053864A5044484602 @default.
• W2187053864 hasAuthorship W2187053864A5053141524 @default.
• W2187053864 hasAuthorship W2187053864A5060571216 @default.
• W2187053864 hasAuthorship W2187053864A5072767524 @default.
• W2187053864 hasAuthorship W2187053864A5084600710 @default.
• W2187053864 hasConcept C104317684 @default.
• W2187053864 hasConcept C105580179 @default.
• W2187053864 hasConcept C121608353 @default.
• W2187053864 hasConcept C126322002 @default.
• W2187053864 hasConcept C134018914 @default.
• W2187053864 hasConcept C150194340 @default.
• W2187053864 hasConcept C153911025 @default.
• W2187053864 hasConcept C172313692 @default.
• W2187053864 hasConcept C502942594 @default.
• W2187053864 hasConcept C530470458 @default.
• W2187053864 hasConcept C54355233 @default.
• W2187053864 hasConcept C55493867 @default.
• W2187053864 hasConcept C71924100 @default.
• W2187053864 hasConcept C84606932 @default.
• W2187053864 hasConcept C86803240 @default.
• W2187053864 hasConcept C96232424 @default.
• W2187053864 hasConceptScore W2187053864C104317684 @default.
• W2187053864 hasConceptScore W2187053864C105580179 @default.
• W2187053864 hasConceptScore W2187053864C121608353 @default.
• W2187053864 hasConceptScore W2187053864C126322002 @default.
• W2187053864 hasConceptScore W2187053864C134018914 @default.
• W2187053864 hasConceptScore W2187053864C150194340 @default.
• W2187053864 hasConceptScore W2187053864C153911025 @default.
• W2187053864 hasConceptScore W2187053864C172313692 @default.
• W2187053864 hasConceptScore W2187053864C502942594 @default.
• W2187053864 hasConceptScore W2187053864C530470458 @default.
• W2187053864 hasConceptScore W2187053864C54355233 @default.
• W2187053864 hasConceptScore W2187053864C55493867 @default.
• W2187053864 hasConceptScore W2187053864C71924100 @default.
• W2187053864 hasConceptScore W2187053864C84606932 @default.
• W2187053864 hasConceptScore W2187053864C86803240 @default.
• W2187053864 hasConceptScore W2187053864C96232424 @default.
• W2187053864 hasIssue "3c" @default.
• W2187053864 hasLocation W21870538641 @default.
• W2187053864 hasOpenAccess W2187053864 @default.
• W2187053864 hasPrimaryLocation W21870538641 @default.

• next