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- W2187068081 abstract "ABSTRACT We have examined the expression of glycogen synthase kinase-3β in oocytes and early embryos of Xenopus and found that the protein is developmentally regulated. In resting oocytes, GSK-3β is active and it is inactivated on maturation in response to progesterone. GSK-3β inactivation is necessary and rate limiting for the cell cycle response to this hormone and the subsequent accumulation of β-catenin. Overexpression of a dominant negative form of the kinase accelerates maturation, as does inactivation by expression of Xenopus Dishevelled or microinjection of an inactivating antibody. Cell cycle inhibition by GSK- 3β is not mediated by the level of β-catenin or by a direct effect on either the MAP kinase pathway or translation of mos and cyclin B1. These data indicate a novel role for GSK-3β in Xenopus development: in addition to controlling specification of the dorsoventral axis in embryos, it mediates cell cycle arrest in oocytes." @default.
- W2187068081 created "2016-06-24" @default.
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- W2187068081 date "1999-02-01" @default.
- W2187068081 modified "2023-09-25" @default.
- W2187068081 title "A novel role for glycogen synthase kinase-3 in <i>Xenopus</i> development: maintenance of oocyte cell cycle arrest by a β-catenin-independent mechanism" @default.
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- W2187068081 doi "https://doi.org/10.1242/dev.126.3.567" @default.
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