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• W2187073395 abstract "Two hundred and fifty female Swiss Albino mice were used to study synergistic anti-tumour activity of propolis to enhance methotrexate activity on mice bearing Ehrlich ascites carcinoma (EAC). They equal divided into 5 groups: 1 st kept as negative control, 2 nd was implanted intraperitoneally with 2.5×10 6 EAC and kept as positive control and, 3 rd implanted intraperitoneally with 2.5×10 6 EAC and treated with propolis by dose (50 mg/kg body weight), were given by gastric intubations 2 hours prior to the intraperitoneal injection of EAC,4 th implanted intraperitoneally with 2.5×10 6 EAC and treated with methotrexate by dose (0.4 mg/kg body weight) and 5 th implanted with the same count of the EAC cells and treated with combination of propolis and methotrexate(50 mg/kg body weight and 0.4 mg/kg body weight,respectively) for eleven successive days . Increasing mean survival time (MST), increasing life span (ILS %) and treated vs. positive control (T/C %) in the all treated groups with increased of the body weight, volume of ascitic fluid, total number of EAC cells, viable % cells and decreased of dead% cells in second group while in groups 3,4 and 5 which treated by trials of propolis ,methotrexate and combination of the two compounds respectively ,revealed decreasing in body weight, volume of the ascitic fluid, total number of EAC cells and the percentage of life cells. Histopathology revealed that least degree of malignancy was in combination group where malignant happens. (Mohamed OT. Badr; Nariman MM Edrees; Amany AM Abdallah; Mohamed A Hashem; Nasr AMN. El-Deen; Ahmed NF. Neamat-Allah and Hager TH Ismail. Synergistic anti-tumour effect of propolis against Ehrlich" @default.
• W2187073395 created "2016-06-24" @default.
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• W2187073395 date "2012-01-01" @default.
• W2187073395 modified "2023-09-25" @default.
• W2187073395 title "Synergistic anti-tumour effect of propolis against Ehrlich carcinoma" @default.
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