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- W2187097259 abstract "1present a post-hoc analysis of the Women’s Health Initiative’s study that evaluated the eff ects of combined hormone-replacement therapy on lung cancer incidence and mortality in postmenopausal women. 1 The investigators had randomised more than 16 500 postmenopausal women to placebo or a combination of conjugated equine oestrogen and medroxyprogesterone acetate. In this analysis, they found that women in the treatment arm had a nonsignifi cant increase in the incidence of lung cancer. These women were also more likely to have increased mortality from lung cancer (hazard ratio 1·71, 95% CI 1·16–2·52), more specifi cally non-small-cell lung cancer. Another interesting aspect was that women who received hormone therapy were more likely to have poorly diff erentiated and metastatic tumours. Thus hormone replacement possibly leads to the development of more aggressive lung cancers and decreases survival in patients who have developed lung cancer. The data on the eff ect of oestrogens on both the incidence of lung cancer and outcomes from lung cancer are controversial. Some previous analyses have suggested that use of hormone-replacement therapy reduced the risk of developing lung cancer especially in smokers, 2–4 possibly due to a lowering of plasma concentrations of insulin-like growth factor 1. 2" @default.
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- W2187097259 date "2009-01-01" @default.
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- W2187097259 title "Another nail in the coffi n for hormone-replacement therapy?" @default.
- W2187097259 hasPublicationYear "2009" @default.
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