FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187122621> ?p ?o ?g. }

• W2187122621 endingPage "36" @default.
• W2187122621 startingPage "27" @default.
• W2187122621 abstract "The aim of the present study was to improve the dissolution, and therefore the bioavailability, of poorly water-soluble tenoxicam. Solid dispersions consisting of tenoxicam with two different types of polymers were prepared. The first type were PVP(30) and β-cyclodextrin and the second type were two superdisintegrants, explotab and croscarmellose sodium. A solid dispersion with an explotab ratio of 1:1 (F(8)) had the best dissolution profile compared to all of the prepared solid dispersions as well as the pure drug, which was then formulated into tablets (T(2)F(8)). T(2)F(8) had far better dissolution than commercial tablets, releasing only 28.3% of the drug, while T(2)F(8) exhibited 96.5% drug release in 20 min. T(2)F(8) was subjected to analytical validation as well as stability studies. The formulation was found to be stable after storage at 40°C for one month, 40°C and 75% relative humidity (40°C/75% RH) for one month, and 60°C for 15 days; this was confirmed by the absence of degraded product prepared in the laboratory by refluxing the drug with 1 N NaOH for 15 min. Infrared (IR) spectroscopy and differential scanning calorimetry (DSC) were performed on T(2)F(8) to identify physicochemical interactions between the drug and carrier, hence its effect on dissolution. A simple and rapid HPLC method was also developed to determine tenoxicam in human plasma and was then used in a pharmacokinetic study. Plasma samples were analyzed on a C(18) column with a mobile phase of 0.02 M sodium acetate:acetonitrile: methanol (7:2.5:0.5, v/v/v) and UV detection at 375 nm. The linear range of the plasma concentration was 1-16 μg/mL with a detection limit of 158 ng/mL. Within-day and between-day precision expressed as the relative standard deviation was less than 2%. The proposed method was successfully used in a bioequivalence study in healthy volunteers and mean pharmacokinetic parameters were calculated." @default.
• W2187122621 created "2016-06-24" @default.
• W2187122621 creator A5014667051 @default.
• W2187122621 creator A5042005019 @default.
• W2187122621 date "2009-02-01" @default.
• W2187122621 modified "2023-09-23" @default.
• W2187122621 title "Enhancement of the dissolution profile of Tenoxicam by a solid dispersion technique and its analytical evaluation using HPLC." @default.
• W2187122621 cites W1498305210 @default.
• W2187122621 cites W1590784435 @default.
• W2187122621 cites W182302348 @default.
• W2187122621 cites W1980809509 @default.
• W2187122621 cites W1986611161 @default.
• W2187122621 cites W1990981870 @default.
• W2187122621 cites W2003481156 @default.
• W2187122621 cites W2008223612 @default.
• W2187122621 cites W2011930026 @default.
• W2187122621 cites W2035828230 @default.
• W2187122621 cites W2045461675 @default.
• W2187122621 cites W2062413569 @default.
• W2187122621 cites W2065892977 @default.
• W2187122621 cites W2077549748 @default.
• W2187122621 cites W2083312474 @default.
• W2187122621 cites W2091147831 @default.
• W2187122621 cites W2093615444 @default.
• W2187122621 cites W2111089104 @default.
• W2187122621 cites W2129537011 @default.
• W2187122621 cites W2151114776 @default.
• W2187122621 cites W2162843941 @default.
• W2187122621 cites W2165947327 @default.
• W2187122621 cites W2259653099 @default.
• W2187122621 cites W2363210948 @default.
• W2187122621 cites W2467102808 @default.
• W2187122621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22495465" @default.
• W2187122621 hasPublicationYear "2009" @default.
• W2187122621 type Work @default.
• W2187122621 sameAs 2187122621 @default.
• W2187122621 citedByCount "4" @default.
• W2187122621 countsByYear W21871226212012 @default.
• W2187122621 countsByYear W21871226212013 @default.
• W2187122621 countsByYear W21871226212016 @default.
• W2187122621 crossrefType "journal-article" @default.
• W2187122621 hasAuthorship W2187122621A5014667051 @default.
• W2187122621 hasAuthorship W2187122621A5042005019 @default.
• W2187122621 hasConcept C112705442 @default.
• W2187122621 hasConcept C120665830 @default.
• W2187122621 hasConcept C121332964 @default.
• W2187122621 hasConcept C13965031 @default.
• W2187122621 hasConcept C14029885 @default.
• W2187122621 hasConcept C142724271 @default.
• W2187122621 hasConcept C155574463 @default.
• W2187122621 hasConcept C177562468 @default.
• W2187122621 hasConcept C178790620 @default.
• W2187122621 hasConcept C179998833 @default.
• W2187122621 hasConcept C181389837 @default.
• W2187122621 hasConcept C185592680 @default.
• W2187122621 hasConcept C204787440 @default.
• W2187122621 hasConcept C2778139025 @default.
• W2187122621 hasConcept C2778432687 @default.
• W2187122621 hasConcept C2781430271 @default.
• W2187122621 hasConcept C39519442 @default.
• W2187122621 hasConcept C42404028 @default.
• W2187122621 hasConcept C43617362 @default.
• W2187122621 hasConcept C71924100 @default.
• W2187122621 hasConcept C88380143 @default.
• W2187122621 hasConcept C97355855 @default.
• W2187122621 hasConcept C98274493 @default.
• W2187122621 hasConceptScore W2187122621C112705442 @default.
• W2187122621 hasConceptScore W2187122621C120665830 @default.
• W2187122621 hasConceptScore W2187122621C121332964 @default.
• W2187122621 hasConceptScore W2187122621C13965031 @default.
• W2187122621 hasConceptScore W2187122621C14029885 @default.
• W2187122621 hasConceptScore W2187122621C142724271 @default.
• W2187122621 hasConceptScore W2187122621C155574463 @default.
• W2187122621 hasConceptScore W2187122621C177562468 @default.
• W2187122621 hasConceptScore W2187122621C178790620 @default.
• W2187122621 hasConceptScore W2187122621C179998833 @default.
• W2187122621 hasConceptScore W2187122621C181389837 @default.
• W2187122621 hasConceptScore W2187122621C185592680 @default.
• W2187122621 hasConceptScore W2187122621C204787440 @default.
• W2187122621 hasConceptScore W2187122621C2778139025 @default.
• W2187122621 hasConceptScore W2187122621C2778432687 @default.
• W2187122621 hasConceptScore W2187122621C2781430271 @default.
• W2187122621 hasConceptScore W2187122621C39519442 @default.
• W2187122621 hasConceptScore W2187122621C42404028 @default.
• W2187122621 hasConceptScore W2187122621C43617362 @default.
• W2187122621 hasConceptScore W2187122621C71924100 @default.
• W2187122621 hasConceptScore W2187122621C88380143 @default.
• W2187122621 hasConceptScore W2187122621C97355855 @default.
• W2187122621 hasConceptScore W2187122621C98274493 @default.
• W2187122621 hasIssue "1" @default.
• W2187122621 hasLocation W21871226211 @default.
• W2187122621 hasOpenAccess W2187122621 @default.
• W2187122621 hasPrimaryLocation W21871226211 @default.
• W2187122621 hasRelatedWork W1973123142 @default.
• W2187122621 hasRelatedWork W1985550170 @default.
• W2187122621 hasRelatedWork W2048272492 @default.
• W2187122621 hasRelatedWork W2081636136 @default.
• W2187122621 hasRelatedWork W2123989749 @default.

• next