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- W2187153114 abstract "The epithelial layers that line the human gut and airways have evolved into tightly regulated mechanical and functional tissue barriers, the mucosae, which have to cope with unrelenting exposure to food- and airborne contaminants. In these barriers, immune cells play a major defensive role. This review describes the most important cellular and molecular mechanisms of mucosal leukocytes during homeostasis and physiological inflammation with a major focus on innate immunity (i.e., the immediate response against potential invaders). In homeostasis, a well-defined mucus layer and the epithelial layer hinder microbes from entering the underlying tissue. In addition, mucosal macrophages are patrolling scavengers with high phagocytic capacity, but their ability to mount an inflammatory response is down-regulated. Innate lymphoid cells also have an important role in maintaining a healthy mucosa. However, if bacteria overcome the barrier they cause an inflammatory reaction aimed at eliminating the threat and re-establishing tissue homeostasis. During the inflammatory response, tissue-resident immune cells become activated and promote the recruitment of monocytes and other leukocytes from the blood to the site of inflammation. The reaction evolves the contribution of mononuclear phagocytes, mast cells, neutrophils and ILCs until the infection is eliminated, tissue damage repaired and homeostasis re-established." @default.
- W2187153114 created "2016-06-24" @default.
- W2187153114 creator A5046054297 @default.
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- W2187153114 creator A5067996327 @default.
- W2187153114 creator A5071425538 @default.
- W2187153114 creator A5080769983 @default.
- W2187153114 date "2014-01-01" @default.
- W2187153114 modified "2023-09-27" @default.
- W2187153114 title "Innate Immune Cells: Key Regulators of Homeostasis and Inflammation in Gut and Airway Mucosae" @default.
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