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- W2187161229 abstract "In this presentation, we report CEM-101 activity measured by reference Clinical and Laboratory Standards Institute (CLSI) methods when testing organisms associated with CARTI (streptococci, Haemophilus spp. and Staphylococcus aureus), emerging resistance subsets and various patterns of MLS B -ketolide resistance found among the tested organisms collected from an international surveillance program in 2008. Background: CEM-101 is a newly developed fluoroketolide with an unusually wide spectrum against pathogens associated with community-acquired bacterial pneumonia (CABP). CEM-101 has a potency generally equal to or 2-fold greater than telithromycin (TEL) or MLS B agents. We report results from a global study of CEM-101 potency and resistance (R) rates for 2008. Methods: 2,901 CABP isolates of S. pneumoniae (SPN; 1738), H. influenzae (HI; 976) and S. aureus (SA; 187) were susceptibility (S) tested by CLSI broth microdilution methods with categorical interpretations (M07-A8, M100-S19) against CEM-101 and >25 comparators. The geographic samples included 1362 strains from the USA, 1273 from Europe (EU) and 266 from Latin America (LA). Results: Organism population characteristics were: SPN penicillin-R (≥2 µg/ml) ranged from 15.9 (LA) to 23.0% (USA), HI β-lactamase production at 14.7 (EU) to 25.4% (USA), and MRSA rates at 40.9 (LA) to 55.0% (USA). Other SPN-R rates were (USA/EU/LA in %); erythromycin (40.0/36.3/20.0), levofloxacin (LEV; 0.6/1.8/0.7), amoxicillin/clavulanate (17.8/8.2/12.4) and ceftriaxone (CRO; 9.7/8.3/4.8). CEM-101 was very potent versus SPN (MIC 50 , 0.015 µg/ml), more potent than TEL and against SA (MIC 50 , 0.06 µg/ml). At the USA-FDA breakpoints for TEL, CEM-101 showed broader coverage for SPN (100.0 vs. 99.8%), HI (99.1 vs. 98.7%) and SA (70.1 vs. 69.5%). These ketolide-S rates were greater than LEV, CRO and all marketed MLS B agents." @default.
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- W2187161229 date "2009-01-01" @default.
- W2187161229 modified "2023-09-27" @default.
- W2187161229 title "First Year Antimicrobial Surveillance Results for CEM-101, a Novel Fluoroketolide with Potent Activity Against Pathogens Associated with Community-acquired Bacterial Pneumonia" @default.
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