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- W2187161621 abstract "Introduction . The aim of the study was to evaluate the efficacy and toxicity of a salvage chemotherapy protocol of ifosfamide and vinorelbine in patients with Hodgkin's disease. The protocol had been originally proposed by V. Bonfante et al. of Instituto Nazionale Tumori of Milan at the session of American Society of Clinical Oncology (ASCO) in 1997. Materials and metho d. The study group consisted of 15 patients with, at least, stage II of Hodgkin's disease, most of them with early relapse. The majority of patients had extranodal involvement and 10 patients had at least three regimens of chemotherapy before. Treatment protocol. Ifosfamide 3 g/m2/day in an 8-hour intravenous infusion for 4 days; uromitexan 3 g/m2/day in 3 divided doses for 4 days; vinorelbine 25 mg/m2 on day 1 and day 5; G-CSF support in a standard dose from day 8 to day 14 of the cycle; chemotherapy cycles were repeated every 21 days. Results . The outlined protocol yielded complete remission in 6 patients, partial remission in 6 patients, stabilisation of the disease process in 2 patients and disease progression in 1 patient. In the complete remission group 3 patients had autologous stem cell transplantation. Treatment toxicity was considered average. The most common side effects included anaemia, neurotoxicity, vomiting, neutropenia and thrombocytopenia. The results of the treatment protocol applied in the pre-selected group of patients may be considered good." @default.
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- W2187161621 date "2002-01-01" @default.
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- W2187161621 title "Ifosfamide and vinorelbine with G-CSF support-chemotherapy protocolis effective in relapse of Hodgkin's disease" @default.
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