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- W2187224154 abstract "Geraldo Marco Rosa JuniorBUCHAIM, R. L.; ANDREO, J. C.; RODRIGUES, A. C.; BUCHAIM, D. V.; ROQUE, D. D.; ROQUE, J. S. & ROSA-JUNIOR,J. M. Bovine bone matrix action associated with morphogenetic protein in bone defects in rats submitted to alcoholism. Int. J. Morphol.,30(1) :266-271, 2012.SUMMARY: Extended excessive alcohol use causes changes in bone tissue, thus affecting osteogenesis. The objective of thisstudy was to evaluate if demineralized bone matrix (Gen-ox®) associated with bone morphogenetic protein (Gen-pro®) changes boneneoformation in rats submitted to experimental alcoholism. Forty male rats ( Rattus norvegicus ) were separated into 2 groups of 20 animalseach: Group E1, which received ethyl alcohol at 25% and had the surgical cavity filled in only with blood clot; and Group E2, whichreceived ethyl alcohol at 25% and had the surgical cavity filled in with demineralized bovine cortical bone associated with bon e morphogeneticprotein. The animals were submitted to a three-week period of gradual adaptation to alcohol, and then continued receiving alcoh ol at 25%for 90 days, when the surgical cavity was made. After the surgery, the animals continued consuming alcohol until reaching the sacrificeperiods of 10, 20, 40, and 60 days, when the tibias were removed for histological processing. Results showed that surgical cavi ty repair andbone marrow reorganization occurred faster in Group E1 than in Group E2. At the end of the experiment, it was observed that animals inGroup E2 had thick bony trabeculae surrounding the implanted material particles and a small area of connective tissue in the surfaceregion. In conclusion, the implanted material did not accelerate bone neoformation, rather it served as a structure for osteogenesis.KEY WORDS: Bone repair; Alcoholism; Xenograft; Bone morphogenetic proteins." @default.
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- W2187224154 date "2012-01-01" @default.
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- W2187224154 title "Bovine Bone Matrix Action Associated With Morphogenetic Protein in Bone Defects in Rats Submitted to Alcoholism Acción de la Matriz Ósea Bovina Asociada a la Proteína Morfogenética en Defectos Óseos en Ratones Sometidos a Alcoholismo" @default.
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