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- W2187242205 abstract "Fludarabine phosphate (F-ara-AMP) shows excellent response rates at low doses (18–30 mg/m2 per day) in indolent lymphoid malignancies without major nonhematologic toxicity [1–5]. In high-dose regimens, however, it caused severe neurotoxic side effects [6–8]. This comparatively narrow therapeutic window requires precise pharmacokinetic studies for optimal dose scheduling. Further, as chronic lymphocytic leukemia (CLL) is the most frequent in this group of malignancies, elderly patients are an important target population for treatment with fludarabine phosphate and might especially benefit from an oral formulation. Therefore studies of its bioavailability are needed. Finally, fludarabine phosphate is currently investigated as a biochemical modulator of cytosine arabinoside [9, 10]." @default.
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- W2187242205 date "1992-01-01" @default.
- W2187242205 modified "2023-09-27" @default.
- W2187242205 title "Plasma Pharmacology of Fludarabine and Cellular Bioavailability of Fludarabine Triphosphate" @default.
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- W2187242205 doi "https://doi.org/10.1007/978-3-642-76591-9_57" @default.
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