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• W2187246947 abstract "Introduction: Anemia of chronic kidney disease (CKD) is associated with poor outcome, including higher death risk in both maintenance dialysis patients and individuals who have CKD stages 3 to 5 and are not yet on dialysis. The cause of anemia in CKD is multi-factorial and includes erythropoietin deficiency, decreased responsiveness to erythropoietin, shortened red blood cell survival, iron deficiency, and chronic inflammation. The identification, evaluation and optimal treatment of anemia of CKD have been detailed in some guidelines and other studies. Essentially these involve determining complete blood count, absolute reticulocyte count, determining serum ferritin to assess iron store and serum transferrin saturation (TSAT) to assess adequacy of iron for erythropoiesis. Aim of Study: Studying the prevalence and predisposing factors of iron deficiency anemia among anemic pre- dialysis CKD patients. Patients and Methods: The study was conducted on 100 anemic pre-dialysis CKD patients (stages IV & V) attended at outpatient clinics of Ain Shams University Hospital . Every patient was subjected to full history taking, full clinical examination, laboratory investigations; kidney function tests (KFT), complete blood count (CBC), and Iron profile. Statistical analysis of data was performed using the SPSS software version 15.0. Results: The study included 38 females and 62 males, their mean age was 50.42±11.5. The most common causes of renal failure were hypertensive kidney disease (HKD) (34%) and diabetic nephropathy (DN) (22%). According to the mean corpuscular volume (MCV); patients were divided into those having normocytic and microcytic anemia (58% and 42% respectively). The prevalence of iron deficiency anemia among the studied patients was 54%. Iron deficiency anemic patients included 20 females and 34 males, their mean age was 49.92±11.13. By Comparison between iron deficiency patients and non iron deficiency patients there were significant differences as regards their serum Iron, Transferrin Saturation (TSAT), serum ferritin and MCV (p≤0.05); being lower among Iron deficiency patients. Among Iron deficiency patients, there were positive correlations between MCV and each of TSAT and serum ferritin (r=0.88, p= 0.00 and r=0.62, p=0.001). Also a positive correlation between hemoglobin (Hb) and serum ferritin was found (r=0.65, p=0.00). Positive correlations were found between TSAT and each of serum iron and Total Iron Binding Capacity (TIBC) (r=0.84, p=0.00 and r=0.52, p=0.005 respectively). Also positive correlations were found between serum ferritin and each of serum iron and TIBC (r=0.59, p=0.001 and r=0.39, p= 0.04). Conclusion: Age, sex, duration of CKD & KFT were insignificant factors affecting the prevalence of Iron deficiency in pre-dialysis patients. MCV was a strong indicator of Iron deficiency anemia when iron study is unavailable or impose economic burden in our developing country. (Howayda A. El shinnawy, Aber H. Baki, Nevine I. Musa and Cherry R. Kamel Iron Deficiency among Anemic Pre-Dialysis Chronic Kidney Disease Patients. Life Sci J 2012;9(1s):127-132) (ISSN:1097-8135). http://www.lifesciencesite.com. 21" @default.
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• W2187246947 date "2012-01-01" @default.
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• W2187246947 title "Iron Deficiency among Anemic Pre-Dialysis Chronic Kidney Disease Patients" @default.
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