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• W2187257625 abstract "Background: Vasomotor symptoms (VMS; hot flashes, hot flushes) are the most common complaints of peri- and postmenopausal women. Therapies include various estrogens and estrogen-progestogen combinations. However, both physicians and patients became concerned about hormone-related therapies following publication of data by the Women’s Health Initiative (WHI) study and have turned to non-hormonal approaches of varying effectiveness and risks. Objective: Comparison of the efficacy of non-hormonal VMS therapies with estrogen replacement therapy (ERT) or ERT combined with progestogen (Menopausal Hormone Treatment; MHT) and the development of literature-based guidelines for the use of hormonal and non-hormonal VMS therapies. Methods: Pubmed, Cochrane Controlled Clinical Trials Register Database and Scopus were searched for relevant clinical trials that provided data on the treatment of VMS up to June 2013. Findings: Depending on the dose, ERT using any of several types of estrogen receptor (ER) ligands is unequivocally the most effective treatment for VMS. In most studies, the selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tibolone, clonidine and gabapentin are more effective than placebo. Paroxetine, which is an SSRI, is the only FDA-approved non-hormonal agent for the treatment of VMS. SSRIs must be used with caution in women with breast cancer receiving adjuvant tamoxifen therapy since SSRIs reduce the metabolism of tamoxifen to its most active metabolite, endoxifen. Although gabapentin and some of the SNRIs may be effective in relieving VMS, there are safety concerns with their use such as increased risk of suicidal thoughts with gabapentin and hepatotoxicity and increased rate of cardiovascular events with desvenlafaxine. Oral micronized progesterone is effective for treatment of VMS in early postmenopausal women. Bazedoxifene/conjugated estrogen may be a promising alternative to hormone therapy for the treatment of VMS. The effects of phytoestrogens on VMS are similar to placebo. Black cohoshes, dong quai, evening primrose oil, ginseng extract, kava kava, vitamin E, red clover leaf, hypnosis, acupuncture are either ineffective or not clinically significantly efficacious in the treatment of VMS. Conclusions: VMS vary greatly in severity, and women with mild to moderate symptoms may not need to use ERT/MHT, or any treatment at all. However if used, ERT or MHT is effective for the treatment of VMS. Initial one to three month trials for efficacy and tolerance are recommended since relief from VMS is usually substantial within 4 weeks of starting ERT/MHT. As with all treatments, the risks and benefits of estrogen treatments and neurotransmitteractive treatments must be reviewed before they are administered. Randomized double blind controlled trials comparing paroxetine, SNRIs, clonidine, dehydroepiandrostenedione or stellate ganglion block with ERT/MHT are needed to confirm their efficacy and side effect profiles. So-called “bioidenticals” have no advantage over conventional preparations and are not subject to FDA standards." @default.
• W2187257625 created "2016-06-24" @default.
• W2187257625 creator A5030128369 @default.
• W2187257625 creator A5066225680 @default.
• W2187257625 creator A5077856324 @default.
• W2187257625 date "2013-01-01" @default.
• W2187257625 modified "2023-09-27" @default.
• W2187257625 title "Hormonal and Non-Hormonal Management of Vasomotor Symptoms: A Narrated Review" @default.
• W2187257625 cites W1486452262 @default.
• W2187257625 cites W1531968143 @default.
• W2187257625 cites W1588513556 @default.
• W2187257625 cites W1805987481 @default.
• W2187257625 cites W1867022828 @default.
• W2187257625 cites W1919419665 @default.
• W2187257625 cites W1968330858 @default.
• W2187257625 cites W1974229225 @default.
• W2187257625 cites W1976389084 @default.
• W2187257625 cites W1977230392 @default.
• W2187257625 cites W1979012706 @default.
• W2187257625 cites W1980766143 @default.
• W2187257625 cites W1990973098 @default.
• W2187257625 cites W1991433627 @default.
• W2187257625 cites W1996328833 @default.
• W2187257625 cites W1998117916 @default.
• W2187257625 cites W1998901719 @default.
• W2187257625 cites W2005769596 @default.
• W2187257625 cites W2006862162 @default.
• W2187257625 cites W2011000720 @default.
• W2187257625 cites W2016117684 @default.
• W2187257625 cites W2016808049 @default.
• W2187257625 cites W2019340572 @default.
• W2187257625 cites W2019979380 @default.
• W2187257625 cites W2020659540 @default.
• W2187257625 cites W2022076582 @default.
• W2187257625 cites W2022246523 @default.
• W2187257625 cites W2026553268 @default.
• W2187257625 cites W2029453104 @default.
• W2187257625 cites W2030888554 @default.
• W2187257625 cites W2036282313 @default.
• W2187257625 cites W2044806508 @default.
• W2187257625 cites W2045244246 @default.
• W2187257625 cites W2048935049 @default.
• W2187257625 cites W2052844510 @default.
• W2187257625 cites W2053048310 @default.
• W2187257625 cites W2053287507 @default.
• W2187257625 cites W2054376446 @default.
• W2187257625 cites W2055243538 @default.
• W2187257625 cites W2055444973 @default.
• W2187257625 cites W2055497969 @default.
• W2187257625 cites W2057968723 @default.
• W2187257625 cites W2058132801 @default.
• W2187257625 cites W2059565405 @default.
• W2187257625 cites W2060589574 @default.
• W2187257625 cites W2061166082 @default.
• W2187257625 cites W2062590377 @default.
• W2187257625 cites W2064970592 @default.
• W2187257625 cites W2067134623 @default.
• W2187257625 cites W2071114199 @default.
• W2187257625 cites W2073883348 @default.
• W2187257625 cites W2076467455 @default.
• W2187257625 cites W2080229353 @default.
• W2187257625 cites W2081510247 @default.
• W2187257625 cites W2083524765 @default.
• W2187257625 cites W2085174974 @default.
• W2187257625 cites W2087048218 @default.
• W2187257625 cites W2088733386 @default.
• W2187257625 cites W2089361437 @default.
• W2187257625 cites W2093978130 @default.
• W2187257625 cites W2095352747 @default.
• W2187257625 cites W2097310500 @default.
• W2187257625 cites W2097412703 @default.
• W2187257625 cites W2097715290 @default.
• W2187257625 cites W2098040946 @default.
• W2187257625 cites W2098663481 @default.
• W2187257625 cites W2098850229 @default.
• W2187257625 cites W2099605448 @default.
• W2187257625 cites W2101744447 @default.
• W2187257625 cites W2102574826 @default.
• W2187257625 cites W2103075983 @default.
• W2187257625 cites W2105918552 @default.
• W2187257625 cites W2108930291 @default.
• W2187257625 cites W2110502449 @default.
• W2187257625 cites W2112732719 @default.
• W2187257625 cites W2119270722 @default.
• W2187257625 cites W2122682603 @default.
• W2187257625 cites W2123511777 @default.
• W2187257625 cites W2123652060 @default.
• W2187257625 cites W2127400192 @default.
• W2187257625 cites W2130175655 @default.
• W2187257625 cites W2130542554 @default.
• W2187257625 cites W2133675074 @default.
• W2187257625 cites W2134310407 @default.
• W2187257625 cites W2135783033 @default.
• W2187257625 cites W2139322035 @default.
• W2187257625 cites W2144156500 @default.
• W2187257625 cites W2145655238 @default.
• W2187257625 cites W2146443363 @default.
• W2187257625 cites W2153332125 @default.
• W2187257625 cites W2153888291 @default.
• W2187257625 cites W2155093024 @default.

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