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- W2187258558 abstract "A fibrin clot is a permeable, viscoelastic matrix. In cardiac surge9 attention is placed on the analysis of clotting Normally, this analysis consists of determining the quantities and effectiveness of biochemical components comprising the coagulation cascade. But this type of analysis does not describe the structure of the clot. The essential function of a clot is to impede the flow of blood. The impedance due to a clot in a vessel is defined by the pressure to flow relabonship, which is governed by the structure of the clot. This structure is affected by the addition of fluids during cardiac surgery. Understanding the character of the completed fibrin clots in vessels is cnhcal. The viscoelastic character and permeability of a clot in a cylindrical tube can be obtained from the analysis of its impedance. The frequency dependence of the impedance is measured with the Vilastic-3 viscoelasticity analyzer. A theoretical model for the viscoelastic matrix consisting of two parallel branches describes the permeable and viscoelastic properties of the clot. In vitro studies show that the model is applicable for clots in a range of vessel sizes approximating small arteries ( 1 to 3 mm in diameter). With the application of the model to fibrin clots formed in the presence of dextran, it is found that dextran increases the clot permeability and decreases the clot viscoelasticity. Fibrin clots where formed from the addition of 0.4 units of thrombin to 1 ml of purified bovine fibrinogen (4 mg/ ml) and 0.1 ml of PBS, 10% dextran T40, or 20% dextran T40 in a cylindrical tube of radius = 0.0927 cm. The frequency dependent impedance of the formed clots (SEE FIGURE) where analyzed with the model. The clot without dextran had a permeability of 1.06 x 10-9 cm2 which increases to 4.25~10~~ and 6.60 xlO-9 in the presence of 1% and 2% dextran, respectively. The viscosity of the clot structure at 2 Hz decreases from 8.98 to 4.96 and 4.00 for O%, 1% and 2% dextran. The elasticity was found to decrease from 49.42 to 43.05 and 31.00 for 0%, 1% and 2% dextran." @default.
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- W2187258558 date "1998-01-01" @default.
- W2187258558 modified "2023-09-24" @default.
- W2187258558 title "The Effects of Fibrin Clots on the Pressure to FIo" @default.
- W2187258558 hasPublicationYear "1998" @default.
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