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- W2187266347 abstract "The methanolic extract of Lycopus europaeus was evaluated on central nervous system. The methanolic extract produced significant sedative effect at the doses of 200, 400 and 600 mg/kg (by oral route), compared to reference substance diazepam in hole board and thiopental -induced sleeping time methods. While the hypnotic effect was calculated at the doses of 800 and 1000 mg/kg via oral pathway significantly reduced in both the reestablishment time and number of head dips during the traction and hole-board tests. In conclusion, these results suggest that the methanolic extract of Lycopus europaeus possess potent sedative and hypnotic activities, which supported its therapeutic use for insomnia." @default.
- W2187266347 created "2016-06-24" @default.
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- W2187266347 date "2013-08-25" @default.
- W2187266347 modified "2023-10-18" @default.
- W2187266347 title "Pharmacological evaluation of sedative and hypnotic activities of methanolic extract of Lycopus europaeus in mice." @default.
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- W2187266347 doi "https://doi.org/10.31254/phyto.2013.2402" @default.
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