FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187300314> ?p ?o ?g. }

• W2187300314 endingPage "L678" @default.
• W2187300314 startingPage "L669" @default.
• W2187300314 abstract "Mechanical stimulation of airway epithelial cells generates the Ca2+ mobilization messenger inositol 1,4,5-trisphosphate and the protein kinase (PK) C activator diacylglycerol. Inositol 1,4,5-trisphosphate diffuses through gap junctions to mediate intercellular communication of the mechanical stimulus (a Ca2+ wave); the role that diacylglycerol-activated PKC might play in the response is unknown. Using primary cultures of rabbit tracheal cells, we show that 12-O-tetradecanoylphorbol 13-acetate- or 1, 2-dioctanyl-sn-glycerol-induced activation of PKC slows the Ca2+ wave, decreases the amplitude of induced intracellular free Ca2+ concentration ([Ca2+]i) increases, and decreases the number of affected cells. The PKC inhibitors bisindolylmaleimide and Gö 6976 slowed the spread of the wave but did not change the number of affected cells. We show that ATP-induced [Ca2+]i increases and oscillations, responses independent of intercellular communication, were inhibited by PKC activators. Bisindolylmaleimide decreased the amplitude of ATP-induced [Ca2+]i increases and blocked oscillations, suggesting that PKC has an initial positive effect on Ca2+ mobilization and then mediates feedback inhibition. PKC activators also reduced the [Ca2+]i increase that followed thapsigargin treatment, indicating a PKC effect associated with the Ca2+ release mechanism." @default.
• W2187300314 created "2016-06-24" @default.
• W2187300314 creator A5002428712 @default.
• W2187300314 creator A5070363446 @default.
• W2187300314 creator A5087492556 @default.
• W2187300314 creator A5089621405 @default.
• W2187300314 date "1999-04-01" @default.
• W2187300314 modified "2023-10-17" @default.
• W2187300314 title "PKC role in mechanically induced Ca²⁺waves and ATP-induced Ca²⁺oscillations in airway epithelial cells" @default.
• W2187300314 cites W1515056746 @default.
• W2187300314 cites W1568328657 @default.
• W2187300314 cites W1593385535 @default.
• W2187300314 cites W1606799581 @default.
• W2187300314 cites W1878818098 @default.
• W2187300314 cites W1896694293 @default.
• W2187300314 cites W1930917734 @default.
• W2187300314 cites W1963560651 @default.
• W2187300314 cites W1979461454 @default.
• W2187300314 cites W2032962887 @default.
• W2187300314 cites W2033049755 @default.
• W2187300314 cites W2045686292 @default.
• W2187300314 cites W2056302193 @default.
• W2187300314 cites W2065045487 @default.
• W2187300314 cites W2069820467 @default.
• W2187300314 cites W2077573563 @default.
• W2187300314 cites W2078576931 @default.
• W2187300314 cites W2080135307 @default.
• W2187300314 cites W2084648916 @default.
• W2187300314 cites W2090160768 @default.
• W2187300314 cites W2096437759 @default.
• W2187300314 cites W2100132948 @default.
• W2187300314 cites W2108541860 @default.
• W2187300314 cites W2123496085 @default.
• W2187300314 cites W2124104395 @default.
• W2187300314 cites W2135890520 @default.
• W2187300314 cites W2141260882 @default.
• W2187300314 cites W2166809896 @default.
• W2187300314 cites W2433847795 @default.
• W2187300314 doi "https://doi.org/10.1152/ajplung.1999.276.4.l669" @default.
• W2187300314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10198365" @default.
• W2187300314 hasPublicationYear "1999" @default.
• W2187300314 type Work @default.
• W2187300314 sameAs 2187300314 @default.
• W2187300314 citedByCount "11" @default.
• W2187300314 countsByYear W21873003142012 @default.
• W2187300314 countsByYear W21873003142013 @default.
• W2187300314 countsByYear W21873003142019 @default.
• W2187300314 crossrefType "journal-article" @default.
• W2187300314 hasAuthorship W2187300314A5002428712 @default.
• W2187300314 hasAuthorship W2187300314A5070363446 @default.
• W2187300314 hasAuthorship W2187300314A5087492556 @default.
• W2187300314 hasAuthorship W2187300314A5089621405 @default.
• W2187300314 hasBestOaLocation W21873003142 @default.
• W2187300314 hasConcept C12554922 @default.
• W2187300314 hasConcept C126322002 @default.
• W2187300314 hasConcept C134018914 @default.
• W2187300314 hasConcept C158157758 @default.
• W2187300314 hasConcept C163235415 @default.
• W2187300314 hasConcept C170493617 @default.
• W2187300314 hasConcept C184235292 @default.
• W2187300314 hasConcept C185592680 @default.
• W2187300314 hasConcept C195794163 @default.
• W2187300314 hasConcept C24998067 @default.
• W2187300314 hasConcept C2776909261 @default.
• W2187300314 hasConcept C2777146706 @default.
• W2187300314 hasConcept C2777314051 @default.
• W2187300314 hasConcept C2777427919 @default.
• W2187300314 hasConcept C2778918659 @default.
• W2187300314 hasConcept C2780610907 @default.
• W2187300314 hasConcept C2781387506 @default.
• W2187300314 hasConcept C36020004 @default.
• W2187300314 hasConcept C41625074 @default.
• W2187300314 hasConcept C55493867 @default.
• W2187300314 hasConcept C71924100 @default.
• W2187300314 hasConcept C79879829 @default.
• W2187300314 hasConcept C86803240 @default.
• W2187300314 hasConcept C88045685 @default.
• W2187300314 hasConcept C95444343 @default.
• W2187300314 hasConceptScore W2187300314C12554922 @default.
• W2187300314 hasConceptScore W2187300314C126322002 @default.
• W2187300314 hasConceptScore W2187300314C134018914 @default.
• W2187300314 hasConceptScore W2187300314C158157758 @default.
• W2187300314 hasConceptScore W2187300314C163235415 @default.
• W2187300314 hasConceptScore W2187300314C170493617 @default.
• W2187300314 hasConceptScore W2187300314C184235292 @default.
• W2187300314 hasConceptScore W2187300314C185592680 @default.
• W2187300314 hasConceptScore W2187300314C195794163 @default.
• W2187300314 hasConceptScore W2187300314C24998067 @default.
• W2187300314 hasConceptScore W2187300314C2776909261 @default.
• W2187300314 hasConceptScore W2187300314C2777146706 @default.
• W2187300314 hasConceptScore W2187300314C2777314051 @default.
• W2187300314 hasConceptScore W2187300314C2777427919 @default.
• W2187300314 hasConceptScore W2187300314C2778918659 @default.
• W2187300314 hasConceptScore W2187300314C2780610907 @default.
• W2187300314 hasConceptScore W2187300314C2781387506 @default.
• W2187300314 hasConceptScore W2187300314C36020004 @default.
• W2187300314 hasConceptScore W2187300314C41625074 @default.
• W2187300314 hasConceptScore W2187300314C55493867 @default.

• next