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- W2187312247 abstract "In view of the potentiality of the triazole nucleus in eliciting various pharmacological properties in particular anticancer potency and the lipophilicity of the substituent groups contributing to influence the bioactivity, has been proposed to synthesize the series of 1, 4-disubstituted 1,2,3-triazoles by utilizing click chemistry, in a one pot synthesis and evaluate them for anticancer activity. A series of 1, 4-disubstituted 1,2,3triazole analogues of phenyls have been prepared. The triazoles 4-(Phenyl-1-(1- phenyl-ethyl)-1H-(1, 2,3) triazole (compound-RK) displayed potent cytotoxic activity against several cancer cell lines with IC50 values in the microomolar range. Phenyl substituent at fourth position and αmethyl benzyl group at first position exhibited the highest activity against HL 60 cells with IC 50" @default.
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- W2187312247 date "2011-01-01" @default.
- W2187312247 modified "2023-09-27" @default.
- W2187312247 title "BIOACTIVITY OF 1, 4-DISUBSTITUTED 1, 2, 3-TRIAZOLES AS CYTOTOXIC AGENTS AGAINST THE VARIOUS HUMAN CELL LINES Research Article" @default.
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