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- W2187403468 abstract "We investigated the association of cytokine gene polymorphisms with the development of chronic myelogenous leukemia (CML) and whether there is an association between gene polymorphisms Th1 and Th2 or regulatory- type cytokines and CML. Thirty patients with CML and 60 healthy controls were enrolled in this study. All genotyping (TNF-α, TGF-β, IL-10, IL-6, and IFN-γ) studies were performed using sequence-specific primers PCR (PCR-SSP). Frequencies of IL-10 (-1082, -819, -592) GCC/ATA (p= 0.009) and IFN-γ; +874 T/A (p= 0.037) polymorphisms were significantly greater in the patients with CML. In contrast, significantly lower frequencies of the IFN-γ A/A (p= 0.004) genotype were observed in patients with CML compared with controls. The results suggest that the IL-10 GCC/ATA and IFN-γ T/A polymorphisms are potential risk factors, and that the IFN-γ A/A polymorphism is a protective factor, for CML in this study group. Bu çalışmada, Th1, Th2 ve T-regülatuar tip sitokin gen polimorfizmleri ile kronik miyeloid lösemi (KML) gelişimi arasIndaki ilişkiyi araştırdık. Bu amaçla çalışmaya 30 KML tanısı almış hasta ve 60 sağlklı gönüllü alındı. Bütün gen tiplendirmeleri (TNF-?, TGF-ß, IL-10, IL-6 ve IFN-?) sekans spesifik primerler kullanılarak PCR yöntemi ile çalışıldı. Hasta grubunda IL-10 (-1082, -819, -592) GCC/ATA (p= 0.009) ve IFN-?; +874 T/A (p= 0.037) polimorfizmleri istatistiksel olarak anlamlı derecede yüksek saptandı. Bunun aksine IFN-? A/A (p= 0.004) genotipi sağlıklı kontrol grubu ile karşılaştırıldığında hasta grubunda düşük sıklıkta saptandı. Bu sonuçlar, çalıştığımız hasta grubu için, IL-10 GCC/ATA ve IFN-? T/A polimorfizmlerinin KML gelişiminde bir risk faktörü, IFN-? A/A polimorfizminin ise koruyucu bir faktör olabileceğini göstermektedir." @default.
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- W2187403468 date "2005-12-05" @default.
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- W2187403468 title "Interleukin-10 and interferon-gamma cytokine gene polymorphisms may be risk factors for chronic myelogenous leukemia." @default.
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