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• W2187409373 abstract "Despitetheprogressofthepasttwodecades,thecauseofAlzheimer’sdisease(AD)andeffectivetreatmentsagainstitremainelusive.The hypothesis that amyloid-(A) peptides are the primary causative agents of AD retains significant support among researchers. Nonetheless,agrowingbodyofevidenceshowsthatApeptidesareunlikelytobethesolefactorinADetiology.EvidencethatA/amyloidindependent factors, including the actions of AD-related genes, also contribute significantly to AD pathogenesis was presented in a symposium at the 2010 Annual Meeting of the Society for Neuroscience. Here we summarize the studies showing how amyloidindependent mechanisms cause defective endo-lysosomal trafficking, altered intracellular signaling cascades, or impaired neurotransmitterreleaseandcontributetosynapticdysfunctionand/orneurodegeneration,leadingtodementiainAD.AviewofADpathogenesis thatencompassesboththeamyloid-dependentand-independentmechanismswillhelpfillthegapsinourknowledgeandreconcilethe findingsthatcannotbeexplainedsolelybytheamyloidhypothesis." @default.
• W2187409373 created "2016-06-24" @default.
• W2187409373 creator A5026743198 @default.
• W2187409373 date "2010-01-01" @default.
• W2187409373 modified "2023-09-27" @default.
• W2187409373 title "Amyloid-IndependentMechanismsinAlzheimer'sDisease Pathogenesis" @default.
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