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- W2187427857 abstract "Patients undergoing an abdominal surgical procedure develop a transient episode of impaired gastrointestinal motility or postoperative ileus. Importantly, postoperative ileus is a major determinant of recovery after intestinal surgery and leads to increased morbidity and prolonged hospitalization, which is a great economic burden to health-care systems. Although a variety of strategies reduce postoperative ileus, including multimodal postoperative rehabilitation (fast-track care) and minimally invasive surgery, none of these methods have been completely successful in shortening the duration of postoperative ileus. The aetiology of postoperative ileus is multifactorial, but insights into the pathogenesis of postoperative ileus have identified intestinal inflammation, triggered by surgical handling, as the main mechanism. The importance of this inflammatory response in postoperative ileus is underscored by the beneficial effect of pharmacological interventions that block the influx of leukocytes. New insights into the pathophysiology of postoperative ileus and the involvement of the innate and the adaptive (T-helper type 1 cell-mediated immune response) immune system offer interesting and important new approaches to prevent postoperative ileus. In this Review, we discuss the latest insights into the mechanisms behind postoperative ileus and highlight new strategies to intervene in the postoperative inflammatory cascade." @default.
- W2187427857 created "2016-06-24" @default.
- W2187427857 creator A5022233995 @default.
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- W2187427857 creator A5075812293 @default.
- W2187427857 creator A5076860618 @default.
- W2187427857 creator A5091026619 @default.
- W2187427857 date "2012-01-01" @default.
- W2187427857 modified "2023-09-27" @default.
- W2187427857 title "New therapeutic strategies for postoperative" @default.
- W2187427857 cites W1480377353 @default.
- W2187427857 cites W1482672461 @default.
- W2187427857 cites W1505424475 @default.
- W2187427857 cites W1516200844 @default.
- W2187427857 cites W1516923186 @default.
- W2187427857 cites W1532331089 @default.
- W2187427857 cites W1583584534 @default.
- W2187427857 cites W1761976336 @default.
- W2187427857 cites W1916243674 @default.
- W2187427857 cites W1938248207 @default.
- W2187427857 cites W1969835738 @default.
- W2187427857 cites W1971992129 @default.
- W2187427857 cites W1974119134 @default.
- W2187427857 cites W1975339995 @default.
- W2187427857 cites W1975727171 @default.
- W2187427857 cites W1977110022 @default.
- W2187427857 cites W1977325109 @default.
- W2187427857 cites W1979005962 @default.
- W2187427857 cites W1979952002 @default.
- W2187427857 cites W1981242756 @default.
- W2187427857 cites W1987362856 @default.
- W2187427857 cites W1987526521 @default.
- W2187427857 cites W1991463185 @default.
- W2187427857 cites W1992910446 @default.
- W2187427857 cites W1995525413 @default.
- W2187427857 cites W1999003615 @default.
- W2187427857 cites W2001974395 @default.
- W2187427857 cites W2003168421 @default.
- W2187427857 cites W2004627686 @default.
- W2187427857 cites W2004862250 @default.
- W2187427857 cites W2005587297 @default.
- W2187427857 cites W2007246387 @default.
- W2187427857 cites W2008160010 @default.
- W2187427857 cites W2008815839 @default.
- W2187427857 cites W2009891928 @default.
- W2187427857 cites W2012219723 @default.
- W2187427857 cites W2012510818 @default.
- W2187427857 cites W2023213901 @default.
- W2187427857 cites W2023631607 @default.
- W2187427857 cites W2025572360 @default.
- W2187427857 cites W2026208410 @default.
- W2187427857 cites W2028491668 @default.
- W2187427857 cites W2029388289 @default.
- W2187427857 cites W2029748187 @default.
- W2187427857 cites W2031872777 @default.
- W2187427857 cites W2034237844 @default.
- W2187427857 cites W2036515306 @default.
- W2187427857 cites W2037694332 @default.
- W2187427857 cites W2039702493 @default.
- W2187427857 cites W2039832247 @default.
- W2187427857 cites W2040072181 @default.
- W2187427857 cites W2049063453 @default.
- W2187427857 cites W2056441723 @default.
- W2187427857 cites W2059290256 @default.
- W2187427857 cites W2060785061 @default.
- W2187427857 cites W2063186822 @default.
- W2187427857 cites W2068379647 @default.
- W2187427857 cites W2069368135 @default.
- W2187427857 cites W2069420729 @default.
- W2187427857 cites W2069696372 @default.
- W2187427857 cites W2073295417 @default.
- W2187427857 cites W2074325726 @default.
- W2187427857 cites W2075586302 @default.
- W2187427857 cites W2077134994 @default.
- W2187427857 cites W2077340116 @default.
- W2187427857 cites W2079327233 @default.
- W2187427857 cites W2084353758 @default.
- W2187427857 cites W2086926240 @default.
- W2187427857 cites W2086972357 @default.
- W2187427857 cites W2087840716 @default.
- W2187427857 cites W2088265742 @default.
- W2187427857 cites W2088989030 @default.
- W2187427857 cites W2094617951 @default.
- W2187427857 cites W2095368589 @default.
- W2187427857 cites W2095563504 @default.
- W2187427857 cites W2096489495 @default.
- W2187427857 cites W2100327483 @default.
- W2187427857 cites W2105724015 @default.
- W2187427857 cites W2107435080 @default.
- W2187427857 cites W2109843404 @default.
- W2187427857 cites W2109963121 @default.
- W2187427857 cites W2111487488 @default.
- W2187427857 cites W2116755169 @default.
- W2187427857 cites W2120521139 @default.
- W2187427857 cites W2122592402 @default.
- W2187427857 cites W2125579943 @default.
- W2187427857 cites W2125875707 @default.
- W2187427857 cites W2126562524 @default.
- W2187427857 cites W2138881175 @default.
- W2187427857 cites W2138898868 @default.