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- W2187436137 abstract "Amongnatural populations ofcapsulate Haemophilus influenzae, clones ofstrains withtypebcapsular polysaccharide arefound ineachoftwowidely separated phylogenetic divisions. Thechromosomal capsulation locus found instrains fromeither division hasathree-segment organization, withserotype-specific DNAnested between elements commontoallserotypes, butpairwise comparison ofthesegments between thedivisions suggests thattheyhavedistinct phylogenetic histories. Genesclustered inoneofthenon-serotype-specific segments appear tohavediverged fromanancestral element, reflected in12%nucleotide sequence divergence inonehomologous pair. Incontrast, genes conferring thecapacity toproduce type-specific polysaccharide exhibit nosuchdivergence, andwespeculate that these havebeensubject morerecently tohorizontal transfer within thebacterial population. Clinically important capsulate gram-negative bacteria sharea common organization oftheir capsulation loci, arguing convergence onasuccessful arrangement ofgenes. InH. influenzae this appears tohaveallowed theoccasional exchange ofserotype-specific capsulation genes between" @default.
- W2187436137 created "2016-06-24" @default.
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- W2187436137 date "1990-01-01" @default.
- W2187436137 modified "2023-09-24" @default.
- W2187436137 title "Capsulation inDistantly Related Strains ofHaemophilus influenzae Typeb:Genetic Drift andGeneTransfer attheCapsulation Locus" @default.
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