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• W2187441671 abstract "<h3>PURPOSE</h3> Depression commonly accompanies diabetes, resulting in reduced adherence to medications and increased risk for morbidity and mortality. The objective of this study was to examine whether a simple, brief integrated approach to depression and type 2 diabetes mellitus (type 2 diabetes) treatment improved adherence to oral hypoglycemic agents and antidepressant medications, glycemic control, and depression among primary care patients. <h3>METHODS</h3> We undertook a randomized controlled trial conducted from April 2010 through April 2011 of 180 patients prescribed pharmacotherapy for type 2 diabetes and depression in primary care. Patients were randomly assigned to an integrated care intervention or usual care. Integrated care managers collaborated with physicians to offer education and guideline-based treatment recommendations and to monitor adherence and clinical status. Adherence was assessed using the Medication Event Monitoring System (MEMS). We used glycated hemoglobin (HbA_1c) assays to measure glycemic control and the 9-item Patient Health Questionnaire (PHQ-9) to assess depression. <h3>RESULTS</h3> Intervention and usual care groups did not differ statistically on baseline measures. Patients who received the intervention were more likely to achieve HbA_1c levels of less than 7% (intervention 60.9% vs usual care 35.7%; <i>P</i> <.001) and remission of depression (PHQ-9 score of less than 5: intervention 58.7% vs usual care 30.7%; <i>P</i> <.001) in comparison with patients in the usual care group at 12 weeks. <h3>CONCLUSIONS</h3> A randomized controlled trial of a simple, brief intervention integrating treatment of type 2 diabetes and depression was successful in improving outcomes in primary care. An integrated approach to depression and type 2 diabetes treatment may facilitate its deployment in real-world practices with competing demands for limited resources." @default.
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• W2187441671 date "2012-01-01" @default.
• W2187441671 modified "2023-10-16" @default.
• W2187441671 title "Integrated Management of Type 2 Diabetes Mellitus and Depression Treatment to Improve Medication Adherence: A Randomized Controlled Trial" @default.
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• W2187441671 doi "https://doi.org/10.1370/afm.1344" @default.
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